Institutes for Systems Genetics, West China Hospital
Copyright @ 2022 ISG. All Rights Reserved.
ncRNA name
UCA1
Specific or universal ncRNAs
Universal ncRNAs
Class
Long noncoding RNA
Biomarker
Yes
Biomarker application
Treatment
Upstream regulatory factors
Not available
Downstream target
miR-196a-5p
Cancer name
Bladder Cancer
Cancer site
Bladder
Treatment type
Chemotherapy
Drug
Cisplatin/Gemcitabine
Impact of wild-type ncRNA on chemotherapy resistance
Up
Impact of knockdown of ncRNA on chemotherapy resistance
Impact of overexpression of ncRNA on chemotherapy resistance
ncRNA differential expression in
cancer
patients vs. healthy people
Not available
Number of patients
Not available
Male patients
Not available
Female patients
Not available
Age range and number
Not available
PMID
Description
Long noncoding RNA UCA1 promotes cisplatin/gemcitabine resistance through CREB modulating miR-196a-5p in bladder cancer cells.
Tissue resource
bladder cancer tissues and paired adjacent normal bladder tissues
bladder cancer cell lines 5637
bladder cancer cell lines UMUC-2
Experiment
qRT-PCR,Western blot,Luciferase reporter assay
Institute
the First Affiliated Hospital of Xi'an Jiaotong University
Country
China
Continent
Asia
Institutes for Systems Genetics, West China Hospital
Copyright @ 2022 ISG. All Rights Reserved.