UCA1

ncRNA information

ncRNA name

UCA1

Specific or universal ncRNAs

Universal ncRNAs

Class

Long noncoding RNA

Biomarker

Yes

Biomarker application

Treatment

Upstream regulatory factors

Not available

Downstream target

miR-196a-5p

Cancer information

Cancer name

Bladder Cancer

Cancer site

Bladder

Treatment information

Treatment type

Chemotherapy

Drug

Cisplatin/Gemcitabine

Impact of wild-type ncRNA on chemotherapy resistance

Up

Impact of knockdown of ncRNA on chemotherapy resistance

Impact of overexpression of ncRNA on chemotherapy resistance

Clinical Information

ncRNA differential expression in
cancer patients vs. healthy people

Not available

Number of patients

Not available

Male patients

Not available

Female patients

Not available

Age range and number

Not available

Research information

PMID

Description

Long noncoding RNA UCA1 promotes cisplatin/gemcitabine resistance through CREB modulating miR-196a-5p in bladder cancer cells.

Tissue resource

bladder cancer tissues and paired adjacent normal bladder tissues

bladder cancer cell lines 5637

bladder cancer cell lines UMUC-2

Experiment

qRT-PCR,Western blot,Luciferase reporter assay


Institute

the First Affiliated Hospital of Xi'an Jiaotong University

Country

China

Continent

Asia