Institutes for Systems Genetics, West China Hospital
Copyright @ 2022 ISG. All Rights Reserved.
ncRNA name
UCA1
Specific or universal ncRNAs
Universal ncRNAs
Class
Long noncoding RNA
Biomarker
No
Biomarker application
Upstream regulatory factors
Not available
Downstream target
miR-18a/HIF1Ī±
Cancer name
Breast Cancer
Cancer site
Breast
Treatment type
Chemotherapy
Drug
Tamoxifen
Impact of wild-type ncRNA on chemotherapy resistance
Up
Impact of knockdown of ncRNA on chemotherapy resistance
Impact of overexpression of ncRNA on chemotherapy resistance
ncRNA differential expression in
cancer
patients vs. healthy people
Not available
Number of patients
Not available
Male patients
Not available
Female patients
Not available
Age range and number
Not available
PMID
Description
Long noncoding RNA UCA1 enhances tamoxifen resistance in breast cancer cells through a miR-18a-HIF1Ī± feedback regulatory loop.
Tissue resource
human breast cancer tamoxifen-sensitive cell lines MCF-7
human breast cancer tamoxifen-resistant cell lines BT474
human breast cancer tamoxifen-resistant cell lines LCC2
human breast cancer tamoxifen-resistant cell lines LCC9
Experiment
qRT-PCR,Western blot,Dual-luciferase reporter assay
Institute
American Type Culture Collection
the Cell Bank of the Chinese Academy of Sciences
Country
USA
China
Continent
Amercia
Asia
Institutes for Systems Genetics, West China Hospital
Copyright @ 2022 ISG. All Rights Reserved.