Institutes for Systems Genetics, West China Hospital
Copyright @ 2022 ISG. All Rights Reserved.
ncRNA name
hsa-miR-141-3p
Specific or universal ncRNAs
Universal ncRNAs
Class
MicroRNA
Biomarker
No
Biomarker application
Upstream regulatory factors
Not available
Downstream target
PTEN
Cancer name
Esophageal Cancer
Cancer site
Esophagus
Treatment type
Chemotherapy
Drug
5-Fluorouracil/Oxaliplatin
Impact of wild-type ncRNA on chemotherapy resistance
Up
Impact of knockdown of ncRNA on chemotherapy resistance
Impact of overexpression of ncRNA on chemotherapy resistance
ncRNA differential expression in
cancer
patients vs. healthy people
Not available
Number of patients
Not available
Male patients
Not available
Female patients
Not available
Age range and number
Not available
PMID
Description
Our study demonstrated that miR-141-3p contributed to an acquired chemo-resistance through PTEN modulation both in vitro and in vivo.
Tissue resource
tumor tissues and their paired adjacent normal esophageal tissues
immortalized human normal esophageal epithelial cell lines Het-1A
human esophageal squamous cell carcinoma cell lines EC109
human esophageal squamous cell carcinoma cell lines EC9706
human esophageal squamous cell carcinoma cell lines TE-1
human esophageal squamous cell carcinoma cell lines KYSE-150
Experiment
qRT-PCR,Western blot,Luciferase reporter assay
Institute
the Second Affiliated Hospital of Xi'an Jiaotong University
American Type Culture Collection
Country
China
USA
Continent
Asia
Amercia
Institutes for Systems Genetics, West China Hospital
Copyright @ 2022 ISG. All Rights Reserved.