Institutes for Systems Genetics, West China Hospital
Copyright @ 2022 ISG. All Rights Reserved.
ncRNA name
hsa-miR-139-5p
Specific or universal ncRNAs
Universal ncRNAs
Class
MicroRNA
Biomarker
Yes
Biomarker application
Treatment
Upstream regulatory factors
Not available
Downstream target
NOTCH1
Cancer name
Colorectal Carcinoma
Cancer site
Colon, Rectum, and Anus
Treatment type
Chemotherapy
Drug
5-Fluorouracil/Mitomycin C
Impact of wild-type ncRNA on chemotherapy resistance
Down
Impact of knockdown of ncRNA on chemotherapy resistance
Impact of overexpression of ncRNA on chemotherapy resistance
ncRNA differential expression in
cancer
patients vs. healthy people
Not available
Number of patients
Not available
Male patients
Not available
Female patients
Not available
Age range and number
Not available
PMID
Description
MiR-139-5p downregulated NOTCH1 signaling to reverse CD44+/CD133+-associated MDR in colorectal cancer cells.
Tissue resource
human colorectal cancer samples and corresponding nontumorous colorectal samples
human colorectal cancer cell lines HCT116
human colorectal cancer cell lines HCT8
Experiment
qRT-PCR,Western blot,Luciferase reporter assay
Institute
Putuo Hospital, Shanghai University of Traditional Chinese Medicine
the Cell Bank of the Type Culture Collection of the Chinese Academy of Sciences
Country
China
Continent
Asia
Institutes for Systems Genetics, West China Hospital
Copyright @ 2022 ISG. All Rights Reserved.