Institutes for Systems Genetics, West China Hospital
Copyright @ 2022 ISG. All Rights Reserved.
ncRNA name
ROR
Specific or universal ncRNAs
Universal ncRNAs
Class
Long noncoding RNA
Biomarker
No
Biomarker application
Upstream regulatory factors
Not available
Downstream target
miR-124/PTBP1/PKM2
Cancer name
Pancreatic Ductal Adenocarcinoma
Cancer site
Pancreas
Treatment type
Chemotherapy
Drug
Gemcitabine
Impact of wild-type ncRNA on chemotherapy resistance
Up
Impact of knockdown of ncRNA on chemotherapy resistance
Impact of overexpression of ncRNA on chemotherapy resistance
ncRNA differential expression in
cancer
patients vs. healthy people
Not available
Number of patients
Not available
Male patients
Not available
Female patients
Not available
Age range and number
Not available
PMID
Description
Linc-ROR confers gemcitabine resistance to pancreatic cancer cells via inducing autophagy and modulating the miR-124/PTBP1/PKM2.
Tissue resource
paired pancreatic ductal adenocarcinoma tissues and adjacent normal tissues
human pancreatic ductal adenocarcinoma cell lines PANC-1
human pancreatic ductal adenocarcinoma cell lines MIAPaCa-2
human pancreatic ductal adenocarcinoma cell lines SW1990
Normal human pancreatic ductal epithelial HPDE6
Experiment
qRT-PCR,Western blot,Dual-luciferase reporter assay
Institute
Chinese PLA General Hospital
American Type Culture Collection
Country
China
USA
Continent
Asia
Amercia
Institutes for Systems Genetics, West China Hospital
Copyright @ 2022 ISG. All Rights Reserved.