hsa-miR-101

ncRNA information

ncRNA name

hsa-miR-101

Specific or universal ncRNAs

Specific ncRNAs

Class

MicroRNA

Biomarker

Yes

Biomarker application

Treatment

Upstream regulatory factors

Not available

Downstream target

GSK3Ī²

Cancer information

Cancer name

Glioblastoma

Cancer site

Brain, Central Nervous System

Treatment information

Treatment type

Chemotherapy

Drug

Temozolomide

Impact of wild-type ncRNA on chemotherapy resistance

Down

Impact of knockdown of ncRNA on chemotherapy resistance

Impact of overexpression of ncRNA on chemotherapy resistance

Clinical Information

ncRNA differential expression in
cancer patients vs. healthy people

Not available

Number of patients

Not available

Male patients

Not available

Female patients

Not available

Age range and number

Not available

Research information

PMID

Description

Our study demonstrates that miR-101 can reverse TMZ resistance by inhibition of GSK3 in GBM.

Tissue resource

primary and recurrent temozolomide-refractory glioblastom samples

glioblastoma cell lines A172

glioblastoma cell lines T98G

glioblastoma cell lines U-251MG

Experiment

qRT-PCR,Western blot,Luciferase reporter assay


Institute

the First Affiliated Hospital of Zhengzhou University

Cell bank of Chinese Academy of Sciences

Country

China

Continent

Asia