CTRR-ncRNA

ncRNA information

ncRNA name

hsa-miR-451

Specific or universal ncRNAs

Universal ncRNAs

Class

MicroRNA

Biomarker

Yes

Biomarker application

Treatment

Upstream regulatory factors

Not available

Downstream target

MYC

Cancer information

Cancer name

Tunisian Chronic Myeloid Leukemia

Cancer site

Leukemia

Treatment information

Treatment type

Chemotherapy

Drug

Imatinib

Impact of wild-type ncRNA on chemotherapy resistance

Up

Impact of knockdown of ncRNA on chemotherapy resistance

Impact of overexpression of ncRNA on chemotherapy resistance

Clinical Information

ncRNA differential expression in
cancer patients vs. healthy people

Not available

Number of patients

59

Male patients

32

Female patients

27

Age range and number

Not available

Research information

PMID

27825294

Description

Downregulated miR-451 was observed in imatinib-resistant CML cases.

Tissue resource

peripheral blood samples from chronic myeloid leukemia patients

Experiment

qRT-PCR

Institute

Pasteur Institute of Tunis

Country

Tunisia

Continent

Africa