Institutes for Systems Genetics, West China Hospital
Copyright @ 2022 ISG. All Rights Reserved.
ncRNA name
hsa-miR-17
Specific or universal ncRNAs
Universal ncRNAs
Class
MicroRNA
Biomarker
Yes
Biomarker application
Treatment
Upstream regulatory factors
Not available
Downstream target
NCOA3
Cancer name
Breast Cancer
Cancer site
Breast
Treatment type
Chemotherapy
Drug
Paclitaxel
Impact of wild-type ncRNA on chemotherapy resistance
Impact of knockdown of ncRNA on chemotherapy resistance
Up
Impact of overexpression of ncRNA on chemotherapy resistance
ncRNA differential expression in
cancer
patients vs. healthy people
Not available
Number of patients
Not available
Male patients
Not available
Female patients
Not available
Age range and number
Not available
PMID
Description
Our results indicated that loss of miR-17 and miR-20b enhanced breast cancer resistance to taxol by upregulating NCOA3 levels.
Tissue resource
breast cancer samples
human breast cancer cell lines MCF-7
human breast cancer cell lines MDAMB-231
breast cancer samples
human breast cancer cell lines MCF-7
human breast cancer cell lines MDAMB-231
Experiment
qRT-PCR,Western blot,Dual-luciferase reporter assay
Institute
The Cancer Center of Guangzhou Medical University
American Type Culture Collection
The Cancer Center of Guangzhou Medical University
American Type Culture Collection
Country
China
USA
China
USA
Continent
Asia
Amercia
Asia
Amercia
Institutes for Systems Genetics, West China Hospital
Copyright @ 2022 ISG. All Rights Reserved.