Institutes for Systems Genetics, West China Hospital
Copyright @ 2022 ISG. All Rights Reserved.
ncRNA name
HOTAIR
Specific or universal ncRNAs
Universal ncRNAs
Class
Long noncoding RNA
Biomarker
No
Biomarker application
Upstream regulatory factors
Not available
Downstream target
PI3K/Akt signaling pathway
Cancer name
Chronic Myeloid Leukemia
Cancer site
Leukemia
Treatment type
Chemotherapy
Drug
Imatinib
Impact of wild-type ncRNA on chemotherapy resistance
Impact of knockdown of ncRNA on chemotherapy resistance
Down
Impact of overexpression of ncRNA on chemotherapy resistance
ncRNA differential expression in
cancer
patients vs. healthy people
Not available
Number of patients
34
Male patients
16
Female patients
18
Age range and number
Not available
PMID
Description
Knockdown of HOTAIR expression downregualted the MRP1 expression levels in the K562-imatinib cells and resulted in higher sensitivity to the imatinib treatment.
Tissue resource
blood from chronic myeloid leukemia patients
human chronic myelogenous leukemia cell lines K562
Experiment
qRT-PCR,Western blot
Institute
the Affiliated Hospital of Weifang Medical University
Zhongyuan Biotech Co., Ltd
Country
China
Continent
Asia
Institutes for Systems Genetics, West China Hospital
Copyright @ 2022 ISG. All Rights Reserved.