Institutes for Systems Genetics, West China Hospital
Copyright @ 2022 ISG. All Rights Reserved.
ncRNA name
HOTAIR
Specific or universal ncRNAs
Universal ncRNAs
Class
Long noncoding RNA
Biomarker
No
Biomarker application
Upstream regulatory factors
Not available
Downstream target
miR-126
Cancer name
Gastric Cancer
Cancer site
Stomach
Treatment type
Chemotherapy
Drug
Cisplatin
Impact of wild-type ncRNA on chemotherapy resistance
Up
Impact of knockdown of ncRNA on chemotherapy resistance
Impact of overexpression of ncRNA on chemotherapy resistance
ncRNA differential expression in
cancer
patients vs. healthy people
Not available
Number of patients
Not available
Male patients
Not available
Female patients
Not available
Age range and number
Not available
PMID
Description
LncRNA HOTAIR promotes cisplatin resistance in gastric cancer by targeting miR-126 to activate the PI3K/AKT/MRP1 genes.
Tissue resource
gastric cancer and corresponding adjacent noncancerous gastric tissues
human gastric cancer cell lines SGC-7901
human gastric cancer cell lines BGC-823
human gastric cancer-cisplatin resistance cell lines SGC-7901/DDP
human gastric cancer-cisplatin resistance cell lines BGC-823/DDP
Experiment
qRT-PCR,Western blot,Dual-luciferase reporter assay
Institute
the First Affiliated Hospital of Nanjing Medical University
the Shanghai Institute of Cell Biology
Country
China
Continent
Asia
Institutes for Systems Genetics, West China Hospital
Copyright @ 2022 ISG. All Rights Reserved.