H19

ncRNA information

ncRNA name

H19

Specific or universal ncRNAs

Universal ncRNAs

Class

Long noncoding RNA

Biomarker

Yes

Biomarker application

Treatment

Upstream regulatory factors

Not available

Downstream target

Not available

Cancer information

Cancer name

Lung Adenocarcinoma

Cancer site

Lung

Treatment information

Treatment type

Chemotherapy

Drug

Cisplatin

Impact of wild-type ncRNA on chemotherapy resistance

Impact of knockdown of ncRNA on chemotherapy resistance

Up

Impact of overexpression of ncRNA on chemotherapy resistance

Clinical Information

ncRNA differential expression in
cancer patients vs. healthy people

Not available

Number of patients

136

Male patients

100

Female patients

36

Age range and number

70(<60)+66(>=60)

Research information

PMID

Description

Knockdown of H19 restored the response of A549/DDP cells to cisplatin.

Tissue resource

lung adenocarcinoma tissues

human lung adenocarcinoma cell lines A549

human lung adenocarcinoma cisplatin-resistant cell lines A549/DDP

Experiment

qRT-PCR,Western blot


Institute

Shanghai Pulmonary Hospital

Country

China

Continent

Asia