Institutes for Systems Genetics, West China Hospital
Copyright @ 2022 ISG. All Rights Reserved.
ncRNA name
H19
Specific or universal ncRNAs
Universal ncRNAs
Class
Long noncoding RNA
Biomarker
Yes
Biomarker application
Treatment
Upstream regulatory factors
Not available
Downstream target
Not available
Cancer name
Lung Adenocarcinoma
Cancer site
Lung
Treatment type
Chemotherapy
Drug
Cisplatin
Impact of wild-type ncRNA on chemotherapy resistance
Impact of knockdown of ncRNA on chemotherapy resistance
Up
Impact of overexpression of ncRNA on chemotherapy resistance
ncRNA differential expression in
cancer
patients vs. healthy people
Not available
Number of patients
136
Male patients
100
Female patients
36
Age range and number
70(<60)+66(>=60)
PMID
Description
Knockdown of H19 restored the response of A549/DDP cells to cisplatin.
Tissue resource
lung adenocarcinoma tissues
human lung adenocarcinoma cell lines A549
human lung adenocarcinoma cisplatin-resistant cell lines A549/DDP
Experiment
qRT-PCR,Western blot
Institute
Shanghai Pulmonary Hospital
Country
China
Continent
Asia
Institutes for Systems Genetics, West China Hospital
Copyright @ 2022 ISG. All Rights Reserved.