hsa-miR-129

ncRNA information

ncRNA name

hsa-miR-129

Specific or universal ncRNAs

Specific ncRNAs

Class

MicroRNA

Biomarker

No

Biomarker application

Upstream regulatory factors

Not available

Downstream target

P-gp

Cancer information

Cancer name

Gastric Cancer

Cancer site

Stomach

Treatment information

Treatment type

Chemotherapy

Drug

Cisplatin

Impact of wild-type ncRNA on chemotherapy resistance

Down

Impact of knockdown of ncRNA on chemotherapy resistance

Impact of overexpression of ncRNA on chemotherapy resistance

Clinical Information

ncRNA differential expression in
cancer patients vs. healthy people

Not available

Number of patients

Not available

Male patients

Not available

Female patients

Not available

Age range and number

Not available

Research information

PMID

Description

These results suggested that miR-129 reversed cisplatin-resistance through inhibiting the P-gp expression in GC cells.

Tissue resource

gastric cancer tissues

human gastric cancer cell lines BGC823

human gastric cancer cell lines MKN45

Experiment

qRT-PCR,Western blot,Luciferase reporter assay


Institute

Changhai Hospital of Shanghai

American Type Culture Collection

Country

China

USA

Continent

Asia

Amercia