Institutes for Systems Genetics, West China Hospital
Copyright @ 2022 ISG. All Rights Reserved.
ncRNA name
hsa-miR-148a
Specific or universal ncRNAs
Universal ncRNAs
Class
MicroRNA
Biomarker
No
Biomarker application
Upstream regulatory factors
Not available
Downstream target
ALCAM
Cancer name
Breast Cancer
Cancer site
Breast
Treatment type
Chemotherapy
Drug
Tamoxifen
Impact of wild-type ncRNA on chemotherapy resistance
Down
Impact of knockdown of ncRNA on chemotherapy resistance
Impact of overexpression of ncRNA on chemotherapy resistance
ncRNA differential expression in
cancer
patients vs. healthy people
Not available
Number of patients
Not available
Male patients
Not available
Female patients
Not available
Age range and number
Not available
PMID
Description
We infer that MiR-148a and miR-152 can sensitize TamR MCF-7 cells to tamoxifen at least via downregulating ALCAM.
Tissue resource
breast tumors samples
tamoxifen sensitive human ER+ breast cancer cell lines MCF-7
breast tumors samples
tamoxifen sensitive human ER+ breast cancer cell lines MCF-7
Experiment
qRT-PCR,Western blot,Luciferase reporter assay
Institute
the Chi-Mei Medical Center
American Type Culture Collection
the Chi-Mei Medical Center
American Type Culture Collection
Country
China
USA
China
USA
Continent
Asia
Amercia
Asia
Amercia
Institutes for Systems Genetics, West China Hospital
Copyright @ 2022 ISG. All Rights Reserved.