hsa-miR-497

ncRNA information

ncRNA name

hsa-miR-497

Specific or universal ncRNAs

Universal ncRNAs

Class

MicroRNA

Biomarker

Yes

Biomarker application

Treatment

Upstream regulatory factors

Not available

Downstream target

mTOR/Bcl-2

Cancer information

Cancer name

Glioma

Cancer site

Brain, Central Nervous System

Treatment information

Treatment type

Chemotherapy

Drug

Temozolomide

Impact of wild-type ncRNA on chemotherapy resistance

Impact of knockdown of ncRNA on chemotherapy resistance

Impact of overexpression of ncRNA on chemotherapy resistance

Up

Clinical Information

ncRNA differential expression in
cancer patients vs. healthy people

Not available

Number of patients

Not available

Male patients

Not available

Female patients

Not available

Age range and number

Not available

Research information

PMID

Description

Up-regulation of miR-497 confers resistance to temozolomide in human glioma cells by targeting mTOR/Bcl-2.

Tissue resource

human glioma cell lines SF295

human glioma cell lines SHG-44

human glioma cell lines U138

human glioma cell lines LN382

human glioma cell lines U87

human glioma cell lines U251

normal human astrocytes cell lines NHA

human embryonic kidney cell lines HEK-293T

Experiment

qRT-PCR,Western blot


Institute

American Type Culture Collection

Country

Continent