CRNDE

ncRNA information

ncRNA name

CRNDE

Specific or universal ncRNAs

Universal ncRNAs

Class

Long noncoding RNA

Biomarker

No

Biomarker application

Upstream regulatory factors

Not available

Downstream target

miR-136

Cancer information

Cancer name

Colorectal Cancer

Cancer site

Colon, Rectum, and Anus

Treatment information

Treatment type

Chemotherapy

Drug

Oxaliplatin

Impact of wild-type ncRNA on chemotherapy resistance

Up

Impact of knockdown of ncRNA on chemotherapy resistance

Impact of overexpression of ncRNA on chemotherapy resistance

Clinical Information

ncRNA differential expression in
cancer patients vs. healthy people

Not available

Number of patients

Not available

Male patients

Not available

Female patients

Not available

Age range and number

Not available

Research information

PMID

Description

Our findings demonstrate that CRNDE functions as a competing endogenous RNA to promote metastasis and OXA resistance by sponging miR-136 in colorectal cancer.

Tissue resource

colorectal cancer tissues

human colorectal adenocarcinoma cell lines SW480

human colorectal adenocarcinoma cell lines HCT116

human colorectal adenocarcinoma cell lines HT-29

Experiment

qRT-PCR,Western blot,Luciferase reporter assay


Institute

Baoji City First People’s Hospital

American Type Culture Collection

Country

China

USA

Continent

Asia

Amercia