Institutes for Systems Genetics, West China Hospital
Copyright @ 2022 ISG. All Rights Reserved.
ncRNA name
CASC2
Specific or universal ncRNAs
Universal ncRNAs
Class
Long noncoding RNA
Biomarker
Yes
Biomarker application
Diagnosis/Treatment
Upstream regulatory factors
Not available
Downstream target
miR-181a/PTEN
Cancer name
Glioma
Cancer site
Brain, Central Nervous System
Treatment type
Chemotherapy
Drug
Temozolomide
Impact of wild-type ncRNA on chemotherapy resistance
Down
Impact of knockdown of ncRNA on chemotherapy resistance
Impact of overexpression of ncRNA on chemotherapy resistance
ncRNA differential expression in
cancer
patients vs. healthy people
Not available
Number of patients
57
Male patients
28
Female patients
29
Age range and number
22(<45)+35(>=45)
PMID
Description
These observations suggest CASC2 up-regulates PTEN through direct inhibiting miR-181a and plays an important role in glioma sensitivity to TMZ and may serve as a potential target for cancer diagnosis and treatment.
Tissue resource
glioma tissues as well as the peritumoral brain edema tissues
human glioma cell lines U251
human glioma cell lines U373
human glioma cell lines SNB19
human glioma cell lines U118
human glioma cell lines LN229
normal cell lines NHA
Experiment
qRT-PCR,Western blot,Luciferase reporter assay
Institute
Xiangya Hospital, Central South University
American Type Culture Collection
Country
China
USA
Continent
Asia
Amercia
Institutes for Systems Genetics, West China Hospital
Copyright @ 2022 ISG. All Rights Reserved.