CASC2

ncRNA information

ncRNA name

CASC2

Specific or universal ncRNAs

Universal ncRNAs

Class

Long noncoding RNA

Biomarker

Yes

Biomarker application

Diagnosis/Treatment

Upstream regulatory factors

Not available

Downstream target

miR-181a/PTEN

Cancer information

Cancer name

Glioma

Cancer site

Brain, Central Nervous System

Treatment information

Treatment type

Chemotherapy

Drug

Temozolomide

Impact of wild-type ncRNA on chemotherapy resistance

Down

Impact of knockdown of ncRNA on chemotherapy resistance

Impact of overexpression of ncRNA on chemotherapy resistance

Clinical Information

ncRNA differential expression in
cancer patients vs. healthy people

Not available

Number of patients

57

Male patients

28

Female patients

29

Age range and number

22(<45)+35(>=45)

Research information

PMID

Description

These observations suggest CASC2 up-regulates PTEN through direct inhibiting miR-181a and plays an important role in glioma sensitivity to TMZ and may serve as a potential target for cancer diagnosis and treatment.

Tissue resource

glioma tissues as well as the peritumoral brain edema tissues

human glioma cell lines U251

human glioma cell lines U373

human glioma cell lines SNB19

human glioma cell lines U118

human glioma cell lines LN229

normal cell lines NHA

Experiment

qRT-PCR,Western blot,Luciferase reporter assay


Institute

Xiangya Hospital, Central South University

American Type Culture Collection

Country

China

USA

Continent

Asia

Amercia