hsa-miR-130b

ncRNA information

ncRNA name

hsa-miR-130b

Specific or universal ncRNAs

Universal ncRNAs

Class

MicroRNA

Biomarker

Yes

Biomarker application

Treatment

Upstream regulatory factors

Not available

Downstream target

PI3K/Akt signaling pathway

Cancer information

Cancer name

Breast Cancer

Cancer site

Breast

Treatment information

Treatment type

Chemotherapy

Drug

Adriamycin

Impact of wild-type ncRNA on chemotherapy resistance

Impact of knockdown of ncRNA on chemotherapy resistance

Impact of overexpression of ncRNA on chemotherapy resistance

Up

Clinical Information

ncRNA differential expression in
cancer patients vs. healthy people

Up

Number of patients

Not available

Male patients

Not available

Female patients

Not available

Age range and number

Not available

Research information

PMID

Description

Over-expression of miR-130b promoted drug resistance, proliferation and decreased apoptosis of MCF-7 cells.

Tissue resource

breast cancer tissues and their adjacent noncancerous tissues

breast cancer cell lines MCF-7

breast cancer adriamycin-resistant cell lines MCF-7/ADR

Experiment

qRT-PCR,Western blot,Luciferase reporter assay


Institute

the First Affiliated Hospital of Dalian Medical University

Nan Jing key GEN Company

Country

China

Continent

Asia