hsa-miR-125b

ncRNA information

ncRNA name

hsa-miR-125b

Specific or universal ncRNAs

Universal ncRNAs

Class

MicroRNA

Biomarker

Yes

Biomarker application

Treatment

Upstream regulatory factors

CXCL12/CXCR4

Downstream target

Not available

Cancer information

Cancer name

Colorectal Cancer

Cancer site

Colon, Rectum, and Anus

Treatment information

Treatment type

Chemotherapy

Drug

5-Fluorouracil

Impact of wild-type ncRNA on chemotherapy resistance

Up

Impact of knockdown of ncRNA on chemotherapy resistance

Impact of overexpression of ncRNA on chemotherapy resistance

Clinical Information

ncRNA differential expression in
cancer patients vs. healthy people

Not available

Number of patients

Not available

Male patients

Not available

Female patients

Not available

Age range and number

Not available

Research information

PMID

Description

Further experiments indicated a role of miR-125b in conferring 5-fluorouracil (5-FU) resistance in CRC probably through increasing autophagy both in vitro and in vivo.

Tissue resource

human colorectal cancer tissue specimens

human colorectal adenocarcinoma cell lines SW620

human colorectal adenocarcinoma cell lines HCT116

Experiment

qRT-PCR,Western blot


Institute

Shandong Tumor Hospital

American Type Culture Collection

Country

China

USA

Continent

Asia

Amercia