Institutes for Systems Genetics, West China Hospital
Copyright @ 2022 ISG. All Rights Reserved.
ncRNA name
MEG3
Specific or universal ncRNAs
Universal ncRNAs
Class
Long noncoding RNA
Biomarker
No
Biomarker application
Upstream regulatory factors
Not available
Downstream target
miR-21
Cancer name
Chronic Myeloid Leukemia
Cancer site
Leukemia
Treatment type
Chemotherapy
Drug
Imatinib
Impact of wild-type ncRNA on chemotherapy resistance
Impact of knockdown of ncRNA on chemotherapy resistance
Impact of overexpression of ncRNA on chemotherapy resistance
Down
ncRNA differential expression in
cancer
patients vs. healthy people
Not available
Number of patients
68
Male patients
38
Female patients
30
Age range and number
Not available
PMID
Description
LncRNA MEG3 Regulates Imatinib Resistance in Chronic Myeloid Leukemia via Suppressing MicroRNA-21.
Tissue resource
peripheral blood samples from chronic myeloid leukemia patients
human leukemic cell lines K562
Experiment
qRT-PCR,Western blot,Luciferase reporter assay
Institute
the Southwest Medical University
American Type Culture Collection
Country
China
USA
Continent
Asia
Amercia
Institutes for Systems Genetics, West China Hospital
Copyright @ 2022 ISG. All Rights Reserved.