Institutes for Systems Genetics, West China Hospital
Copyright @ 2022 ISG. All Rights Reserved.
ncRNA
hsa-miR-449a
Specific or universal ncRNAs
Universal ncRNAs
Class
MicroRNA
Biomarker
Yes
Biomarker application
Treatment
Upstream regulatory factor
Not available
Downstream target
Notch1
Differential expression in
recurrence vs. nonrecurrence
Not available
Cancer name
Hepatocellular Carcinoma
Alias
Liver Cancer
Cancer site
Liver
Recurrence type
Recurrence
Overall survival rate of patients with
high ncRNA expression
Up
ncRNA differential expression in
cancer
patients vs. health people
Not available
Number of patients
Not available
Male patients
Not available
Female patients
Not available
Age range and number
Not available
Recurrence patients
Not available
Recurrence patients male:female
Not available
Recurrence patients age range
Not available
Recurrence mean age
Not available
Sites of recurrence
Not available
Patients without recurrence
Not available
Patients without recurrence male:female
Patients without recurrence age range
Not available
Patients without recurrence mean age
Not available
PMID
Description
MiR-449a is short-term recurrence-related miRNA and inhibits the invasion and metastasis ability of HCC cells by regulating EMT via Notch pathway.
Tissue resource
normal hepatic cell lines HL-7702
hepatocellular carcinomaC cell lines hepatocellular carcinomaLM3
hepatocellular carcinoma cell lines BEL-7402
hepatocellular carcinoma cell lines QGY-7703
hepatocellular carcinoma cell lines SMMC-7721
hepatocellular carcinoma tissue samples with short-term recurrence
Experiment
qRT-PCR,Western blot,Luciferase reporter assay
Institute
the Cell Resource Center of the Shanghai Institutes for Sciences
the Affiliated Hospital of Qingdao University
Country
China
Continent
Asia
Institutes for Systems Genetics, West China Hospital
Copyright @ 2022 ISG. All Rights Reserved.