Alzheimer's Disease Cooperative Study

Content
Basic information

Name: Alzheimer's Disease Cooperative Study

Abbreviation: ADCS

Versions: 7

Synonyms: 229

Description: The Alzheimer Disease Assessment Scale (ADAS) consists of cognitive and noncognitive sections. Its cognitive section (ADAS-Cog) (Fig. 7.2) includes not only standard tests of language, comprehension, memory, and orientation but also tests of visual-spatial ability, such as drawing geometric figures, and physical tasks that reflect ideational praxis, such as folding a paper into an envelope. Patients obtain scores of 0 to 70 with higher scores indicating poorer performance. Compared to the MMSE, the ADAS-Cog is more sensitive, reliable, and less influenced by educational level and language skills. However, it is more complex and subjective. Test-givers, who need not be physicians, must undergo special training. The testing usually requires 45 to 60 minutes. Alzheimer disease researchers, especially those involved in pharmaceutical trials, routinely use the ADAS-Cog to monitor the course of Alzheimer disease and measure the effect of medication. (Dementia Centre for Research Collaboration, https://www.sciencedirect.com/topics/medicine-and-dentistry/alzheimer-disease-assessment-scale)

Reference: Amariglio RE, Donohue MC, Marshall GA, Rentz DM, Salmon DP, Ferris SH, Karantzoulis S, Aisen PS, Sperling RA. Tracking early decline in cognitive function in older individuals at risk for Alzheimer disease dementia: the Alzheimer's Disease Cooperative Study Cognitive Function Instrument. JAMA neurology. 2015 Apr. PMID: 25706191. PMCID: PMC4397164 DOI: 10.1001/jamaneurol.2014.3375

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Temporal prevalence

Distribution in different diseases

Distribution in different versions

# version trials
1 Alzheimer's Disease Cooperative Study-Activities of Daily Living 278
2 Alzheimer's Disease Cooperative Study-Clinical Global Impression of Change 83
3 Alzheimer's Disease Cooperative Study-Instrumental Activities of Daily Living 21
4 modified Alzheimer's Disease Cooperative Study-Clinical Global Impression of Change 9
5 Alzheimer's Disease Cooperative Study 5
6 Alzheimer's Disease Cooperative Study-Preclinical Alzheimer Cognitive Composite 3
7 modified Alzheimer's Disease Cooperative Study-Activities of Daily Living 2
Complementary instruments

# instruments trials
1 Alzheimer's Disease Assessment Scale 247
2 Mini-Mental State Examination 208
3 Neuropsychiatric Inventory 189
4 Clinical Dementia Rating Scale 137
5 Clinician's Interview Based Impression of Change 44
6 Clinical Global Impression 31
7 Quality of Life in Alzheimer's Disease Scale 30
8 EQ-5D 30
9 Resource Utilization in Dementia Scale 27
10 Trail Making Test 26
11 Severe Impairment Battery 24
12 Zarit Burden Interview 23
13 Montreal Cognitive Assessment 22
14 Geriatric Depression Scale 20
15 Columbia Suicide Severity Rating Scale 18
16 Cohen-Mansfield Agitation Inventory 17
17 Integrated Alzheimer's Disease Rating Scale 16
18 Cornell Scale for Depression in Dementia 14
19 Functional Activities Questionnaire 14
20 Neuropsychological Test Battery 14
21 Unified Parkinson's Disease Rating Scale 13
22 Category Fluency Test 11
23 Repeatable Battery for the Assessment of Neuropsychological Status 11
24 Activities of Daily Living 8
25 Dementia Quality of Life Instrument 8
26 Wechsler Adult Intelligence Scale 8
27 Instrumental Activities of Daily Living 7
28 Short Form Health Survey 7
29 Visual Analogue Scale 7
30 Frontal Assessment Battery 7
31 Digit Span Task 7
32 Free and Cued Selective Reminding Test 7
33 Wechsler Memory Scale 7
34 Cambridge Neuropsychological Test Automated Battery 6
35 Stroop Test 6
36 Global Deterioration Scale 6
37 CogState 6
38 Controlled Oral Word Association Test 6
39 Alzheimer's Disease Composite Score 6
40 Behavioral Pathology in Alzheimer's Disease Rating Scale 5
41 Digit Symbol Substitution Test 5
42 Digit Symbol Coding Task 5
43 Apathy Evaluation Scale 4
44 Disability Assessment for Dementia Scale 4
45 Clock Drawing Test 4
46 Dependence Scale 4
47 Pittsburgh Sleep Quality Index 4
48 Quality of Life Questionnaire 4
49 Verbal Fluency Test 4
50 Hamilton Depression Rating Scale 4
51 Cognitive Drug Research Battery 4
52 Epworth Sleepiness Scale 4
53 Caregiver Burden Inventory 4
54 Short Physical Performance Battery 4
55 Patient Health Questionnaire 4
56 Patient Global Impression 4
57 Frontal Behavioral Inventory 3
58 Delis-Kaplan Executive Function System 3
59 Beck Depression Inventory 3
60 Rey's Auditory Verbal Learning Test 3
61 Mini Nutritional Assessment 3
62 Goal Attainment Scale 3
63 Time Up and Go Test 3
64 Generalized Anxiety Disorder Scale-7 3
65 Satisfaction Scale 3
66 Addenbrooke's Cognitive Examination 3
67 Starkstein Apathy Scale 3
68 Letter Fluency Task 3
69 Clinical Assessment of Fluctuation 3
70 Global Statistical Test 3
71 Early and Mild Alzheimer's Cognitive Composite 3
72 Buschke Selective Reminding Test 2
73 Hopkins Verbal Learning Test 2
74 Behavioral and Psychological Symptoms of Dementia 2
75 Montgomery-Åsberg Depression Rating Scale 2
76 Udvalg for Kliniske Undersøgelser (UKU) Side Effect Rating Scale 2
77 Caregiver Activity Survey 2
78 Pain Assessment in Advanced Dementia Scale 2
79 Alzheimer's Disease Related Quality of Life 2
80 Logical Memory Test 2
81 Ten Point Clock Test 2
82 Wechsler Logical Memory Scale 2
83 Clinician's Interview Based Impression of Severity 2
84 Word List Learning Test 2
85 Caregiver Burden Scale 2
86 Partner-Patient Questionnaire for Shared Activities 2
87 Mixed Model Repeated Measures 2
88 Verbal Rating Scale 2
89 International Shopping List Test 2
90 Patient-Reported Outcomes Measurement Information System 2
91 Composite Cognition Score-3 Domain 2
92 Semantic Fluency Test 2
93 Balance Evaluation System Test 2
94 Mayo Fluctuations Scale 2
95 National Institutes of Health Toolbox 2
96 Letter Digit Substitution Test 2
97 General Medical Health Rating 2
98 Sheehan Suicidality Tracking Scale 2
99 Smell Identification Test 2
100 Hachinski Ischemic Score 2
101 Homeostasis Model Assessment for Insulin Resistance 2
102 Irritability Apathy Scale 2
103 Problem Behaviours Assessment 2
104 Caregiver Self-Assessment Questionnaire 2
105 Caregiver Strain Instrument 2
106 Brief Psychiatric Rating Scale 1
107 The Executive Interview 1
108 Memory and Behavior Problems Checklist 1
109 Functional Assessment Staging Test 1
110 Mattis Dementia Rating Scale 1
111 Physical Self-Maintenance Scale 1
112 Benton Visual Retention Task 1
113 Pittsburgh Agitation Scale 1
114 Color Trails Test 1
115 Symbol Digit Modalities Test 1
116 California Verbal Learning Test 1
117 Continuous Performance Test 1
118 Nurses' Observation Scale for Geriatric Patients 1
119 Quality of Life Scale 1
120 Quality of Life in Late-Stage Dementia Scale 1
121 Western Aphasia Battery 1
122 modified Crichton Scale 1
123 Delayed Word Recall 1
124 Caregiver Strain Index 1
125 Stokes Social Network Scale 1
126 Cambridge Mental Disorders of the Elderly Examination 1
127 Boston Naming Test 1
128 Functional Assessment Questionnaire 1
129 Screen for Caregiver Burden 1
130 Treatment Outcome Scale 1
131 Positive and Negative Affect Schedule 1
132 Test for the Early Detection of Dementia With Discrimination From Depression 1
133 World Health Organization Quality of Life 1
134 F-A-S Test 1
135 Unified Huntington's Disease Rating Scale 1
136 Fall Efficacy Scale 1
137 American National Adult Reading Test 1
138 Resource Utilization in Dementia Questionnaire 1
139 Zung Self-Rating Depression Scale 1
140 Burden Interview 1
141 Computerised Test Battery 1
142 Block Design Test 1
143 Letter Number Sequencing task 1
144 Physical Performance Test 1
145 Selective Reminding Task 1
146 Burden Inventory 1
147 Questionnaire for Urinary Incontinence Diagnosis 1
148 Word Fluency Test 1
149 Health Care Resources Utilization Questionnaire 1
150 Fazekas Scale 1
151 Hospital Anxiety and Depression Scale 1
152 Impact of Alzheimer's Disease on Caregiver Questionnaire 1
153 Dot Counting Test 1
154 Physical Activity Scale for the Elderly 1
155 Investigator's Global Evaluation Scale 1
156 Delayed Story Recall 1
157 Pain Assessment Checklist for Seniors with Limited Ability to Communicate 1
158 Frontotemporal Dementia Rating Scale 1
159 Abnormal Visual Acuity Test 1
160 Lens Opacities Classification System 1
161 Michigan Neuropathy Screening Instrument 1
162 Parkinson's Disease Questionnaire 1
163 Clock Draw Interpretation Scale 1
164 Brief Coping Orientation to Problems Experienced Inventory 1
165 Geriatric Evaluation of Mental Status 1
166 Brief Visuospatial Memory Test 1
167 Cognitive Test Battery 1
168 Multilingual Naming Test 1
169 Chinese version of Executive Interview 1
170 Verbal Learning Test 1
171 NIH EXAMINER 1
172 One Day Fluctuation Assessment Scale 1
173 Cogstate Brief Battery 1
174 Continuous Oral Word Association Task 1
175 Preclinical Alzheimer's Cognitive Composite 1
176 Young Mania Rating Scale 1
177 Ruler Drop Test 1
178 Psychological Well-Being Scale 1
179 Prospective and Retrospective Memory Questionnaire 1
180 Scales for Outcomes in Parkinson's Disease 1
181 Care Transitions Measur 1
182 Confusion Assessment Method 1
183 Full Analysis Set 1
184 ALGOPLUS SCALE 1
185 Resource Use Inventory 1
186 Wisconsin Card Sorting Test 1
187 Clinical Dyskinesia Rating Scale 1
188 Gait Task 1
189 UCSD Performance-Based Skills Assessment 1
190 Treatment Satisfaction Questionnaire for Medication 1
191 Parkinson's Disease Cognitive Rating Scale 1
192 Quantitative Movement Testing 1
193 Global Physical Activity Questionnaire 1
194 Caregiver Medication Questionnaire 1
195 Mayo Sleep Questionnaire 1
196 Behavioral Indicators Test 1
197 Global Rating of Fall Risk 1
198 Physical Mobility Scale 1
199 Test of Everyday Attention 1
200 Approaches to Dementia Questionnaire 1
201 Questionnaire for Impulsive-Compulsive Disorders in Parkinson's Disease 1
202 Columbia Classification Algorithm for Suicide Assessment 1
203 Sense of Competence in Dementia Care Staff 1
204 Penn Parkinson's Daily Activities Questionnaire 1
205 Physician Withdrawal Checklist 1
206 Incontinency Frequency Rating 1
207 Quality of Life Enjoyment and Satisfaction Questionnaire 1
208 Richards-Campbell Sleep Questionnaire 1
209 Winterlight Speech Assessment 1
210 Quick Dementia Rating Scale 1
211 Altoida Neuro Motor Index 1
212 ADCOMS 1
213 Pattern Separation Task 1
214 Visual Association Memory Test 1
215 NIH Alzheimer's Disease Centers 1
216 Screening for Aphasia in NeuroDegeneration Scale 1
217 Dementia Apathy Interview Rating 1
218 Medical History Interview 1
219 Screening Interview 1
220 Structured Telephone Interview 1
221 Leisure-Time Activities Questionnaire 1
222 Word and Category Fluency Test 1
223 Dementia Syndrome Classification Scale 1
224 Multidimensional Psychological Questionnaire 1
225 SPARK Test Cognitive Impairment Index 1
226 Anger Management Scale 1
227 Pain and Sleep Questionnaire 1
228 Cognitive Self-Report Questionnaire 1
229 Autoimmunity Marker Screening Test 1
230 Penn Daily Activities Questionnaire 1
231 Cognitive Drug Research Computerized Assessment System 1