Basic information
Biomarker: miR-146a-5p
Histology type: endometrial carcinoma
Cohort characteristics
Country: China
Region: Nanjing
Followed up time :
Subgroup 1 name : external validation
Subgroup 1 number: 27
Subgroup 2 name: controls
Subgroup 2 number: 23
Cohort statistics: cutoff<50;cutoff>50
| Total number | Group I | Group I number | Group II | Group II number | Group III | Group III number | Group IV | Group IV number |
|---|---|---|---|---|---|---|---|---|
| 172 | endometrial cancer | 93 | healthy | 79 |
Sample information
Description: A signature consisting of 3 plasma miRNAs was identified and showed potential for the non-invasive diagnosis of EC.
Sample type : plasma
Sample method: qRT-PCR
Expression pattern : Ct-value < 37, 1.5-fold altered expression in EC patients compared with healthy controls
Expression elevation: The expression of miRNAs in plasma or exosomes was calculated using the 2−∆∆Ct method (cel-miR-39 as exogenous reference miRNA for plasma samples; RNU6B (U6) [U6] for tissue sample normalization; ∆Ct = Ct miRNA − Ct normalizer; Ct: the threshold cycle)
Disease information
Cohort age: 22;28
Subgroup 1 age: 9;18
Subgroup 2 age: 13;10
Related information
HGNC miRNA approved symbol: MIR146A
HGNC miRNA approved name: microRNA 146a
HGNC miRNA locus type: RNA, micro
HGNC miRNA symbol status: Approved
HGNC miRNA ID: HGNC:31533
HGNC miRNA link: https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:31533
Stem loop sequence symbol: hsa-mir-146a
Stem loop sequence accession: MI0000477
Stem loop sequence gene family: MIPF0000103
Stem loop sequence annotation confidence: high
Mature sequence symbol: hsa-miR-146a-5p$ hsa-miR-146a-3p
Mature sequence accession: MIMAT0000449 $ MIMAT0004608
Previous IDs: hsa-miR-146;hsa-miR-146a $hsa-miR-146a*
Evidence: experimental; cloned [PMID:15800047,PMID:17604727],experimental; cloned [ PMID:17604727]
miRBase link: https://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0000477
