Basic information
Biomarker: Pax2
Histology type: endometrial cancer
Cohort characteristics
Country: USA
Region: TX
Followed up time :
| Total number | Group I | Group I number | Group II | Group II number | Group III | Group III number | Group IV | Group IV number |
|---|---|---|---|---|---|---|---|---|
| 190 | AH/EIN | 111 | normal controls | 79 |
Sample information
Conclusion: The results unequivocally demonstrate that some lesions that do not approach current histologic thresholds are bona fide neoplastic precursors with clinically-relevant driver events that can be detected by the 3-marker panel. The findings provide further validation for the diagnostic utility of the panel in clinical practice and its application in difficult or ambiguous cases.
Sample type : tissue
Sample method: immunocytochemistry
Disease information
Related information
Funtion Uniprot: Transcription factor that may have a role in kidney cell differentiation (PubMed:24676634). Has a critical role in the development of the urogenital tract, the eyes, and the CNS
UniProt ID: Q02962
UniProt Link: https://www.uniprot.org/uniprotkb/Q02962
Biological function from UniProt: #Differentiation #Transcription #Transcription regulation
Molecular function from UniProt:
Tissue specificity from UniProt: Expressed in primitive cells of the kidney, ureter, eye, ear and central nervous system.
Recommended name: Paired box protein Pax-2
Gene name from HGNC: PAX2
HPA class: Disease related genes Human disease related genes Transcription factors
AlphaFold DB: Q02962
AlphaFold Link: https://alphafold.ebi.ac.uk/entry/Q02962
HPA link: https://www.proteinatlas.org/ENSG00000075891-PAX2
Tissue specificity RNA from HPA: Group enriched (epididymis, kidney)
Tissue expression from HPA: Kidney - Transmembrane transport (mainly)
Single cell type specificity Group enriched (Glandular and luminal cells, Collecting duct cells)
Immune cell specificity: Not detected in immune cells
Subcellular summary HPA #Nucleus
Cancer prognostic summary HPA Prognostic marker in endometrial cancer (unfavorable)
Pathology link: https://www.proteinatlas.org/ENSG00000075891-PAX2/pathology
Pathology endo: https://www.proteinatlas.org/ENSG00000075891-PAX2/pathology/endometrial+cancer
Phenotype ID: Papillorenal syndrome (PAPRS)
OMIM: MIM:120330
OMIM link1: https://www.omim.org/entry/120330
HGNC ID: HGNC:8616
HGNC link: https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:8616
