Basic information
Biomarker: calponin
Histology type: benign tumor
Cohort characteristics
Country: China
Region: Beijing
Study type: Comparative Study
Followed up time :
Subgroup 1 name : Positive in EST
Subgroup 1 number: 5
Subgroup 2 name: negative in EST
Subgroup 2 number: 16
| Total number | Group I | Group I number | Group II | Group II number | Group III | Group III number | Group IV | Group IV number |
|---|---|---|---|---|---|---|---|---|
| 41 | uterine endometrial stromal tumors (EST) | 21 | highly cellular leiomyoma (HCL) | 20 |
Sample information
Conclusion: Highly cellular leiomyomas have distinct morphologic features. H-caldesmon, calponin, CD10, desmin and SMA are helpful in the differential diagnosis of HCL and EST.
Sample type : tissue
Sample method: immunohistochemistry
Expression pattern : expression
Disease information
Related information
Funtion Uniprot: Thin filament-associated protein that is implicated in the regulation and modulation of smooth muscle contraction. It is capable of binding to actin, calmodulin and tropomyosin. The interaction of calponin with actin inhibits the actomyosin Mg-ATPase activity (By similarity).
UniProt ID: P51911
UniProt Link: https://www.uniprot.org/uniprotkb/P51911/entry
Molecular function from UniProt:
Tissue specificity from UniProt: Smooth muscle, and tissues containing significant amounts of smooth muscle.
Alternative name from UniProt:
Recommended name: Calponin-1
Gene name from HGNC: CNN1 (Sm-Calp, SMCC)
HPA class: Cancer-related genes
AlphaFold DB: P51911
AlphaFold Link: https://alphafold.ebi.ac.uk/entry/P51911
HPA link: https://www.proteinatlas.org/ENSG00000130176-CNN1
Tissue specificity RNA from HPA: Tissue enhanced (endometrium, intestine, smooth muscle)
Tissue expression from HPA: Highly selective cytoplasmic expression in smooth muscle and myoepithelial cells.
Single cell type specificity Group enriched (Late spermatids, Early spermatids, Peritubular cells, Breast myoepithelial cells, Smooth muscle cells)
Immune cell specificity: Not detected in immune cells
Subcellular summary HPA Located in Actin filaments (Single cell variability)
Cancer prognostic summary HPA Prognostic marker in renal cancer (unfavorable)
Pathology link: https://www.proteinatlas.org/ENSG00000130176-CNN1/pathology
Pathology endo: https://www.proteinatlas.org/ENSG00000130176-CNN1/pathology/endometrial+cancer
OMIM: 600806
OMIM link2: https://www.omim.org/entry/600806
HGNC ID: HGNC:2155
HGNC link: https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:2155
