Biomarker: CaMKIV

Histology type: endometrial carcinoma

Stage: stage

Country: Japan

Region: Oita

Followed up time :

Conclusion: Our results demonstrate that CaMKIV expression in endometrial carcinoma correlates with the malignant potential of this tumor.

Sample type : tissue

Sample method: fluorescent immunohistochemistry

Expression pattern : expression

Funtion Uniprot: Calcium/calmodulin-dependent protein kinase that operates in the calcium-triggered CaMKK-CaMK4 signaling cascade and regulates, mainly by phosphorylation, the activity of several transcription activators, such as CREB1, MEF2D, JUN and RORA, which play pivotal roles in immune response, inflammation, and memory consolidation. In the thymus, regulates the CD4+/CD8+ double positive thymocytes selection threshold during T-cell ontogeny. In CD4 memory T-cells, is required to link T-cell antigen receptor (TCR) signaling to the production of IL2, IFNG and IL4 (through the regulation of CREB and MEF2). Regulates the differentiation and survival phases of osteoclasts and dendritic cells (DCs). Mediates DCs survival by linking TLR4 and the regulation of temporal expression of BCL2. Phosphorylates the transcription activator CREB1 on 'Ser-133' in hippocampal neuron nuclei and contribute to memory consolidation and long term potentiation (LTP) in the hippocampus. Can activate the MAP kinases MAPK1/ERK2, MAPK8/JNK1 and MAPK14/p38 and stimulate transcription through the phosphorylation of ELK1 and ATF2. Can also phosphorylate in vitro CREBBP, PRM2, MEF2A and STMN1/OP18

UniProt ID: Q16566

UniProt Link: https://www.uniprot.org/uniprotkb/Q16566/entry

Biological function from UniProt: #Adaptive immunity #Immunity #Inflammatory response

Molecular function from UniProt:

Tissue specificity from UniProt: Expressed in brain, thymus, CD4 T-cells, testis and epithelial ovarian cancer tissue.

Subcellular UniProt: #Cytoplasm #Nucleus

Alternative name from UniProt:

Catalytic activity: ATP + L-seryl-[protein] = ADP + H+ + O-phospho-L-seryl-[protein]$ATP + L-threonyl-[protein] = ADP + H+ + O-phospho-L-threonyl-[protein]

Activity regulation: Activated by Ca2+/calmodulin. Binding of calmodulin results in conformational change that relieves intrasteric autoinhibition and allows phosphorylation of Thr-200 within the activation loop by CaMKK1 or CaMKK2. Phosphorylation of Thr-200 results in a 10-20-fold increase in total activity to generate Ca2+/calmodulin-independent activity. Autophosphorylation of the N-terminus Ser-12 and Ser-13 is required for full activation. Inactivated by protein phosphatase 2A (PPP2CA/PPP2CB) which dephosphorylates Thr-200, thereby terminating autonomous activity and helping to maintain the enzyme in its autoinhibited state.

Recommended name: Calcium/calmodulin-dependent protein kinase type IV

Gene name from HGNC: CAMK4 (CaMK-GR, CaMKIV)

HPA class: Enzymes Metabolic proteins

AlphaFold DB: Q16566

AlphaFold Link: https://alphafold.ebi.ac.uk/entry/Q16566

Developmental stage: Expressed during differentiation of monocyte-derived dendritic cells (at protein level).

HPA link: https://www.proteinatlas.org/ENSG00000152495-CAMK4

Tissue specificity RNA from HPA: Group enriched (brain, lymphoid tissue)

Tissue expression from HPA: Nuclear and cytoplasmic expression at variable levels in several tissues, most abundant in CNS.

Single cell type specificity Cell type enhanced (Early spermatids, Excitatory neurons, Oligodendrocyte precursor cells, Inhibitory neurons, Late spermatids, T-cells, Bipolar cells)

Immune cell specificity: Group enriched (naive CD4 T-cell, MAIT T-cell, T-reg, naive CD8 T-cell, memory CD4 T-cell, memory CD8 T-cell)

Subcellular summary HPA Located in Nucleoplasm, Nucleoli fibrillar center

Cancer prognostic summary HPA Gene product is not prognostic

Pathology link: https://www.proteinatlas.org/ENSG00000152495-CAMK4/pathology

Pathology endo: https://www.proteinatlas.org/ENSG00000152495-CAMK4/pathology/endometrial+cancer

OMIM: 114080

OMIM link2: https://www.omim.org/entry/114080

HGNC ID: HGNC:1464

HGNC link: https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:1464