Biomarker: P-cadherin

Histology type: endometrial carcinoma

Country: Norway

Region: Hordaland

Followed up time :

Subgroup 1 name : low

Subgroup 1 number: 151

Subgroup 2 name: high

Subgroup 2 number: 135

Conclusion: Differential expression of P-cadherin and beta-catenin seems to be important in endometrial carcinoma and is associated with aggressive subgroups. Our findings also indicate that a shift from E-cadherin to P-cadherin expression (cadherin switch) is an important prognostic feature in these tumors.

Sample type : tissue

Sample method: immunohistochemistry

Expression pattern : high expression

Expression elevation: For P-cadherin, tumors were classified by the upper quartile as high expressing (SI ≥ 6) or low expressing (SI<6). Regarding p120ctn, samples were classified by the lower quartile as low expressing (SI< 3) or high expressing (SI ≥ 3).

Funtion Uniprot: Cadherins are calcium-dependent cell adhesion proteins. They preferentially interact with themselves in a homophilic manner in connecting cells; cadherins may thus contribute to the sorting of heterogeneous cell types.

UniProt ID: P22223

UniProt Link: https://www.uniprot.org/uniprotkb/P22223/entry

Biological function from UniProt: #Cell adhesion #Sensory transduction #Vision

Molecular function from UniProt:

Tissue specificity from UniProt: Expressed in some normal epithelial tissues and in some carcinoma cell lines.

Subcellular UniProt: #Cell membrane #Membrane

Alternative name from UniProt:

Recommended name: Cadherin-3

Gene name from HGNC: CDH3 (CDHP, PCAD)

HPA class: Disease related genes Human disease related genes

AlphaFold DB: P22223

AlphaFold Link: https://alphafold.ebi.ac.uk/entry/P22223

HPA link: https://www.proteinatlas.org/ENSG00000062038-CDH3

Tissue specificity RNA from HPA: Tissue enhanced (choroid plexus, ovary)

Tissue expression from HPA: Membranous expression squamous epithelia.

Single cell type specificity Cell type enhanced (Basal respiratory cells, Pancreatic endocrine cells, Granulosa cells, Basal squamous epithelial cells, Basal prostatic cells, Basal keratinocytes, Melanocytes)

Immune cell specificity: Not detected in immune cells

Subcellular summary HPA Located in Plasma membrane, Cell Junctions

Cancer prognostic summary HPA Prognostic marker in pancreatic cancer (unfavorable) and lung cancer (unfavorable)

Pathology link: https://www.proteinatlas.org/ENSG00000062038-CDH3/pathology

Pathology endo: https://www.proteinatlas.org/ENSG00000062038-CDH3/pathology/endometrial+cancer

Phenotype ID: 601553;225280;

Disease: Hypotrichosis congenital with juvenile macular dystrophy (HJMD);Ectodermal dysplasia, ectrodactyly, and macular dystrophy syndrome (EEMS);

Note1: The disease is caused by variants affecting the gene represented in this entry;The disease is caused by variants affecting the gene represented in this entry;

OMIM: 114021

OMIM link1: https://www.omim.org/entry/601553;https://www.omim.org/entry/225280;

OMIM link2: https://www.omim.org/entry/114021

HGNC ID: HGNC:1762

HGNC link: https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:1762