Biomarker: versican

Histology type: endometrial carcinoma

Country: Japan

Region: Okayama

Followed up time :

Subgroup 1 name : negative in epithelial versican expression

Subgroup 1 number: 131

Subgroup 2 name: positive in epithelial versican expression

Subgroup 2 number: 36

Conclusion: Versican enrichment of the stroma may be associated with tumor progression in endometrial cancer. Stromal versican expression can serve as an indicator of poor prognosis for patients with endometrial cancer.

Sample type : tissue

Sample method: immunohistochemistry

Expression pattern : high expression( High stromal expression, strong and moderate staining; low stromal expression, weak and no staining)

Expression elevation: The level of versican immunoreactivity in the stroma was expressed by classifying the area of peri- and intratumoral versican-positive stroma into four groups: strong, >50% of the stroma stained; moderate, 10%–50% of the stroma stained; weak, <10% of the stroma stained;and negative, no staining.We also evaluated versican-positive cancer cells. Any case with cancer cellassociated versican staining was considered as positive. Microscopic analyses were evaluated independently by two of the authors who had no prior knowledge of the clinical data. F

Statictics: cutoff<70;cutoff>70

Cohort age: 141;26

Subgroup 1 age: 109;22

Subgroup 2 age: 32;4

Funtion Uniprot: May play a role in intercellular signaling and in connecting cells with the extracellular matrix. May take part in the regulation of cell motility, growth and differentiation. Binds hyaluronic acid.

UniProt ID: P13611

UniProt Link: https://www.uniprot.org/uniprotkb/P13611/entry

Molecular function from UniProt:

Tissue specificity from UniProt: Expressed in the retina (at protein level) (PubMed:29777959). Cerebral white matter and plasma (PubMed:2469524). Isoform V0: Expressed in normal brain, gliomas, medulloblastomas, schwannomas, neurofibromas, and meningiomas (PubMed:8627343). Isoform V1: Expressed in normal brain, gliomas, medulloblastomas, schwannomas, neurofibromas, and meningiomas (PubMed:8627343). Isoform V2: Restricted to normal brain and gliomas (PubMed:8627343). Isoform V3: Found in all these tissues except medulloblastomas (PubMed:8627343).

Subcellular UniProt: #Cell projection #Extracellular matrix #Secreted

Alternative name from UniProt:

Recommended name: Versican core protein

Gene name from HGNC: VCAN (CSPG2, PG-M)

HPA class: Disease related genes Human disease related genes Plasma proteins

Developmental stage: Expressed in developing photoreceptors and the interphotoreceptor matrix between 12 and 17 weeks post conception (at protein level) (PubMed:29777959). Disappears in aorta after the cartilage development (PubMed:7921538).

HPA link: https://www.proteinatlas.org/ENSG00000038427-VCAN

Tissue specificity RNA from HPA: Low tissue Low tissue specificityy

Tissue expression from HPA: Expression mainly in extracellular matrix in most tissues and in dentate nucleus.

Single cell type specificity Cell type enhanced (Oligodendrocyte precursor cells, Granulosa cells, Endometrial stromal cells, monocytes, Macrophages, Kupffer cells)

Immune cell specificity: Group enriched (classical monocyte, myeloid DC)

Subcellular summary HPA Located in Vesicles (Single cell variability)

Cancer prognostic summary HPA Prognostic marker in stomach cancer (unfavorable), renal cancer (unfavorable) and melanoma (unfavorable)

Pathology link: https://www.proteinatlas.org/ENSG00000038427-VCAN/pathology

Pathology endo: https://www.proteinatlas.org/ENSG00000038427-VCAN/pathology/endometrial+cancer

Phenotype ID: 143200

Disease: Wagner vitreoretinopathy (WGVRP)

Note1: The disease is caused by variants affecting the gene represented in this entry. The pathological mechanism involves a quantitative imbalance of the normally occurring splice variants (PubMed:22739342)

OMIM: 118661

OMIM link1: https://www.omim.org/entry/143200

OMIM link2: https://www.omim.org/entry/118661

HGNC ID: HGNC:2464

HGNC link: https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:2464