Biomarker: SATB2

Histology type: endometrioid endometrial carcinoma

Country: USA

Region: MI

Followed up time :

Subgroup 1 name : negative in myoinvasive endometrioid carcinomas

Subgroup 1 number: 25

Subgroup 2 name: positive in myoinvasive endometrioid carcinomas

Subgroup 2 number: 4

Conclusion: Patchy to diffuse SATB2 and block-type p16 staining of fibromuscular stroma separating atypical endometrioid glands is more consistent with atypical polypoid adenomyomathan with myoinvasive endometrioid endometrial carcinoma .

Sample type : tissue

Sample method: staining

Expression pattern : patchy to diffuse SATB2 and block-type p16 staining

Expression elevation: The intensity (weak, moderate, or strong) and extent (focal/patchy versus diffuse) of nuclear SATB2 staining in the epithelial and stromal components of each lesion were recorded.

Statictics: Mean

Cohort age: 41

Funtion Uniprot: Binds to DNA, at nuclear matrix- or scaffold-associated regions. Thought to recognize the sugar-phosphate structure of double-stranded DNA. Transcription factor controlling nuclear gene expression, by binding to matrix attachment regions (MARs) of DNA and inducing a local chromatin-loop remodeling. Acts as a docking site for several chromatin remodeling enzymes and also by recruiting corepressors (HDACs) or coactivators (HATs) directly to promoters and enhancers. Required for the initiation of the upper-layer neurons (UL1) specific genetic program and for the inactivation of deep-layer neurons (DL) and UL2 specific genes, probably by modulating BCL11B expression. Repressor of Ctip2 and regulatory determinant of corticocortical connections in the developing cerebral cortex. May play an important role in palate formation. Acts as a molecular node in a transcriptional network regulating skeletal development and osteoblast differentiation.

UniProt ID: Q9UPW6

UniProt Link: https://www.uniprot.org/uniprotkb/Q9UPW6/entry

Biological function from UniProt: #Transcription #Transcription regulation

Molecular function from UniProt:

Tissue specificity from UniProt: High expression in adult brain, moderate expression in fetal brain, and weak expression in adult liver, kidney, and spinal cord and in select brain regions, including amygdala, corpus callosum, caudate nucleus, and hippocampus.

Subcellular UniProt: #Nucleus

Alternative name from UniProt:

Recommended name: DNA-binding protein SATB2

Gene name from HGNC: SATB2 (FLJ21474, KIAA1034)

HPA class: Disease related genes Human disease related genes Transcription factors

AlphaFold DB: Q9UPW6

AlphaFold Link: https://alphafold.ebi.ac.uk/entry/Q9UPW6

HPA link: https://www.proteinatlas.org/ENSG00000119042-SATB2

Tissue specificity RNA from HPA: SATB2 (FLJ21474, KIAA1034)

Tissue expression from HPA: Selective nuclear expression in large intestine and subsets of neuronal cells in brain.

Single cell type specificity Cell type enhanced (Excitatory neurons, Distal enterocytes, Enteroendocrine cells, Undifferentiated cells, Paneth cells, Intestinal goblet cells)

Immune cell specificity: Not detected in immune cells

Subcellular summary HPA Located in Nucleoplasm

Cancer prognostic summary HPA Prognostic marker in renal cancer (favorable)

Pathology link: https://www.proteinatlas.org/ENSG00000119042-SATB2/pathology

Phenotype ID: ;119540;

Disease: No disease ID;Cleft palate isolated (CPI);

Note1: Chromosomal aberrations involving SATB2 are found in isolated cleft palate. Translocation t(2;7); translocation t(2;11);The disease may be caused by variants affecting the gene represented in this entry;

OMIM: 608148

OMIM link1: https://www.omim.org/entry/119540

OMIM link2: https://www.omim.org/entry/608148

HGNC ID: HGNC:21637

HGNC link: https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:21637