Biomarker: E-cadherin

Histology type: endometrioid endometrial carcinoma

Stage: aggressive phenotype

Country: China

Region: Shanghai

Study type: retrospective study

Followed up time :

Subgroup 1 name : negative

Subgroup 1 number: 69

Subgroup 2 name: positive

Subgroup 2 number: 55

Conclusion: These results demonstrated for the first time that the hypoxia-inducible factor 1α/TWIST/E-cadherin pathway may play a critical role in invasion and metastasis of endometrioid endometrial carcinoma. The combined evaluation of these markers may be useful in predicting aggressive phenotypes and thus prognosis in patients with endometrioid endometrial carcinoma.

Sample type : tissue

Sample method: immunohistochemistry

Expression pattern : expression (hypoxia-inducible factor 1α+TWIST+E-cadherin )

Expression elevation: The sum of the intensity and extent points was used as the final staining scores (0 – 7),preserved E-cadherin expression (score 3) or reduced E-cadherin expression (scores 0, 1 and 2).

Statictics: Median;Range

Cohort age: 57;27-81

Funtion Uniprot: Cadherins are calcium-dependent cell adhesion proteins (PubMed:11976333). They preferentially interact with themselves in a homophilic manner in connecting cells; cadherins may thus contribute to the sorting of heterogeneous cell types. CDH1 is involved in mechanisms regulating cell-cell adhesions, mobility and proliferation of epithelial cells (PubMed:11976333). Has a potent invasive suppressor role. It is a ligand for integrin alpha-E/beta-72 Publications E-Cad/CTF2 promotes non-amyloidogenic degradation of Abeta precursors. Has a strong inhibitory effect on APP C99 and C83 production.1 Publication (Microbial infection) Serves as a receptor for Listeria monocytogenes; internalin A (InlA) binds to this protein and promotes uptake of the bacteria.3 Publications

UniProt ID: P12830

UniProt Link: https://www.uniprot.org/uniprotkb/P12830/entry

Molecular function from UniProt:

Tissue specificity from UniProt: Non-neural epithelial tissues.

Subcellular UniProt: #Cell junction #Cell membrane #Endosome #Golgi apparatus #Membrane

Alternative name from UniProt:

Recommended name: Cadherin-1

Gene name from HGNC: CDH1 (CD324, UVO, uvomorulin)

HPA class: Cancer-related genes CD markers Disease related genes Human disease related genes Plasma proteins

AlphaFold DB: P12830

AlphaFold Link: https://alphafold.ebi.ac.uk/entry/P12830

Induction: Expression is repressed by MACROD1.

HPA link: https://www.proteinatlas.org/ENSG00000039068-CDH1

Tissue specificity RNA from HPA: Tissue enhanced (parathyroid gland)

Tissue expression from HPA: Cytoplasmic and membranous expression in epithelial cells.

Single cell type specificity Cell type enhanced (Distal enterocytes, Glandular and luminal cells, Pancreatic endocrine cells)

Immune cell specificity: Group enriched (plasmacytoid DC, myeloid DC)

Subcellular summary HPA Located in Golgi apparatus, Plasma membrane, Cell Junctions (Single cell variability)

Cancer prognostic summary HPA Prognostic marker in renal cancer (favorable)

Pathology link: https://www.proteinatlas.org/ENSG00000039068-CDH1/pathology

Pathology endo: https://www.proteinatlas.org/ENSG00000039068-CDH1/pathology/endometrial+cancer

Phenotype ID: 137215;608089

Disease: Hereditary diffuse gastric cancer (HDGC);Endometrial cancer (ENDMC)| Ovarian cancer (OC)|Breast cancer, lobular (LBC)|Blepharocheilodontic syndrome 1 (BCDS1)

Note1: Disease susceptibility is associated with variants affecting the gene represented in this entry. Heterozygous CDH1 germline mutations are responsible for familial cases of diffuse gastric cancer. Somatic mutations has also been found in patients with sporadic diffuse gastric cancer and lobular breast cancer;Disease susceptibility is associated with variants affecting the gene represented in this entry| Disease susceptibility is associated with variants affecting the gene represented in this entry |The gene represented in this entry may be involved in disease pathogenesis |The disease is caused by variants affecting the gene represented in this entry|

OMIM: 192090

OMIM link1: https://www.omim.org/entry/137215|https://www.omim.org/entry/608089|https://www.omim.org/entry/137215|https://www.omim.org/entry/119580

OMIM link2: https://www.omim.org/entry/192090

HGNC ID: HGNC:1748

HGNC link: https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:1748