Biomarker: hPEBP4

Histology type: endometrioid endometrial carcinoma

Country: China

Region: Shanghai

Followed up time :

Conclusion: The expression pattern of hPEBP4 indicated that hPEBP4 interacted with ER and PR in EEC and could thus become a possible target for the development of novel treatment against this malignancy.

Sample type : tissue

Sample method: immunohistochemistry

Expression pattern : expression

Expression elevation: The immunohistochemical staining resulting from each field was analyzed semiquantitatively by the sum or product of intensity and extensity (the proportion of the cells stained under a microscopic field). For hPEBP4, the extensity was graded as follows: 0 for 0-10% of tumor cells stained; 1 for 11-25% of cells stained; 2 for 26-50% of cells stained; and 3 for >50% of cells stained. Intensity of staining was graded as follows: 1 for light yellow; 2 for dark yellow; and 3 for brown. The final value of each slide was obtained from the sum of these two factors as follows: 0 for negative (1-2), 1 for mild (3), 2 for moderate (4), and 3 for strong (5-6).

Statictics: Mean (SD);Range

Cohort age: 53.6;31-72

Funtion Uniprot: Promotes AKT phosphorylation, suggesting a possible role in the PI3K-AKT signaling pathway.

UniProt ID: Q96S96

UniProt Link: https://www.uniprot.org/uniprotkb/Q96S96/entry

Molecular function from UniProt:

Subcellular UniProt: #Secreted

Alternative name from UniProt:

Caution: It was previously reported that PEBP4 is a lysosomal protein which is highly expressed in tumor cells, and may promote cellular resistance to TNF-induced apoptosis. However the paper has since been retracted by the journal due to concerns of image manipulation

Recommended name: Phosphatidylethanolamine-binding protein 4

Gene name from HGNC: PEBP4 (CORK1, hPEBP4, MGC22776)

HPA class: Plasma proteins

AlphaFold DB: Q96S96

AlphaFold Link: https://alphafold.ebi.ac.uk/entry/Q96S96

HPA link: https://www.proteinatlas.org/ENSG00000134020-PEBP4

Tissue specificity RNA from HPA: Tissue enhanced (epididymis, skeletal muscle, tongue)

Tissue expression from HPA: plasma protein.

Single cell type specificity Group enriched (Muller glia cells, Alveolar cells type 2, Cardiomyocytes, Alveolar cells type 1)

Immune cell specificity: Not detected in immune cells

Cancer prognostic summary HPA Gene product is not prognostic

Pathology link: https://www.proteinatlas.org/ENSG00000134020-PEBP4/pathology

Pathology endo: https://www.proteinatlas.org/ENSG00000134020-PEBP4/pathology/endometrial+cancer

OMIM: 612473

OMIM link2: https://www.omim.org/entry/612473

HGNC ID: HGNC:28319

HGNC link: https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:28319