Basic information
Biomarker: HE4
Histology type: endometrioid endometrial carcinoma
Stage: high risk
Cohort characteristics
Country: Australia
Region: Australian National Endometrial Cancer Study (ANECS)
Study type: Perioperative
Followed up time :
| Total number | Group I | Group I number | Group II | Group II number | Group III | Group III number | Group IV | Group IV number |
|---|---|---|---|---|---|---|---|---|
| 373 | EC | 373 |
Sample information
Conclusion: These findings demonstrate the utility of serum HE4 as a prognostic biomarker in endometrial cancer in a large, population-based study. In particular they highlight the utility of HE4 for pre-operative risk stratification to identify high-risk patients within low-grade endometrioid endometrial cancer patients who might benefit from lymphadenectomy.
Sample type : serum
Sample method: ARCHITECT instrument
Expression pattern : threshold of 70 pmol/L
Disease information
Statictics: Mean (SD)
Cohort age: 61.2 ±0.52
Related information
Funtion Uniprot: Broad range protease inhibitor.
UniProt ID: Q14508
UniProt Link: https://www.uniprot.org/uniprotkb/Q14508/entry
Molecular function from UniProt:
Tissue specificity from UniProt: Expressed in a number of normal tissues, including male reproductive system, regions of the respiratory tract and nasopharynx. Highly expressed in a number of tumors cells lines, such ovarian, colon, breast, lung and renal cells lines. Initially described as being exclusively transcribed in the epididymis.
Subcellular UniProt: #Secreted
Alternative name from UniProt:
Recommended name: WAP four-disulfide core domain protein 2
Gene name from HGNC: WFDC2 (dJ461P17.6, EDDM4, HE4, WAP5)
HPA class: Cancer-related genes
AlphaFold DB: Q14508
AlphaFold Link: https://alphafold.ebi.ac.uk/entry/Q14508
HPA link: https://www.proteinatlas.org/ENSG00000101443-WFDC2
Tissue specificity RNA from HPA: Tissue enhanced (cervix, salivary gland)
Tissue expression from HPA: Cytoplasmic expression in selected tissues.
Immune cell specificity: Not detected in immune cells
Subcellular summary HPA Secreted
Cancer prognostic summary HPA Prognostic marker in glioma (unfavorable) and renal cancer (favorable)
Pathology link: https://www.proteinatlas.org/ENSG00000101443-WFDC2/pathology
Pathology endo: https://www.proteinatlas.org/ENSG00000101443-WFDC2/pathology/endometrial+cancer
OMIM: 617548
OMIM link2: https://www.omim.org/entry/617548
HGNC ID: HGNC:15939
HGNC link: https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:15939
