Biomarker: survivin

Histology type: endometrial carcinoma

Country: Japan

Region: Tokyo

Followed up time :

Conclusion: Present study indicated that survivin expression is a significant prognostic factor and that survivin is a promising therapeutic target for endometrial cancer.

Expression pattern : high expression(median expression level as a threshold)

Funtion Uniprot: Multitasking protein that has dual roles in promoting cell proliferation and preventing apoptosis (PubMed:9859993, PubMed:21364656, PubMed:20627126, PubMed:25778398, PubMed:28218735). Component of a chromosome passage protein complex (CPC) which is essential for chromosome alignment and segregation during mitosis and cytokinesis (PubMed:16322459). Acts as an important regulator of the localization of this complex; directs CPC movement to different locations from the inner centromere during prometaphase to midbody during cytokinesis and participates in the organization of the center spindle by associating with polymerized microtubules (PubMed:20826784). Involved in the recruitment of CPC to centromeres during early mitosis via association with histone H3 phosphorylated at 'Thr-3' (H3pT3) during mitosis (PubMed:20929775). The complex with RAN plays a role in mitotic spindle formation by serving as a physical scaffold to help deliver the RAN effector molecule TPX2 to microtubules (PubMed:18591255). May counteract a default induction of apoptosis in G2/M phase (PubMed:9859993). The acetylated form represses STAT3 transactivation of target gene promoters (PubMed:20826784). May play a role in neoplasia (PubMed:10626797). Inhibitor of CASP3 and CASP7 (PubMed:21536684). Essential for the maintenance of mitochondrial integrity and function (PubMed:25778398). Isoform 2 and isoform 3 do not appear to play vital roles in mitosis (PubMed:12773388, PubMed:16291752). Isoform 3 shows a marked reduction in its anti-apoptotic effects when compared with the displayed wild-type isoform (PubMed:10626797).

UniProt ID: O15392

UniProt Link: https://www.uniprot.org/uniprotkb/O15392/entry

Biological function from UniProt: #Apoptosis #Cell cycle #Cell division #Chromosome partition #Mitosis

Molecular function from UniProt:

Tissue specificity from UniProt: Expressed only in fetal kidney and liver, and to lesser extent, lung and brain (PubMed:10626797). Abundantly expressed in adenocarcinoma (lung, pancreas, colon, breast, and prostate) and in high-grade lymphomas (PubMed:14741722, PubMed:16329164). Also expressed in various renal cell carcinoma cell lines (PubMed:10626797). Expressed in cochlea including the organ of Corti, the lateral wall, the interdental cells of the Limbus as well as in Schwann cells and cells of the cochlear nerve and the spiral ganglions (at protein level). Not expressed in cells of the inner and outer sulcus or the Reissner's membrane (at protein level) (PubMed:21364656, PubMed:20627126).

Subcellular UniProt: #Centromere #Chromosome #Cytoplasm #Cytoskeleton #Kinetochore

Alternative name from UniProt:

Recommended name: Baculoviral IAP repeat-containing protein 5

Gene name from HGNC: BIRC5 (API4, EPR-1, survivin)

HPA class: Cancer-related genes

AlphaFold DB: O15392

AlphaFold Link: https://alphafold.ebi.ac.uk/entry/O15392

Induction: Up-regulated by COMP

Developmental stage: Expression is cell cycle-dependent and peaks at mitosis

HPA link: https://www.proteinatlas.org/ENSG00000089685-BIRC5

Tissue specificity RNA from HPA: Tissue enhanced (bone marrow, lymphoid tissue, testis)

Tissue expression from HPA: Distinct nuclear expression mainly in a fraction of cells in squamous epithelia, lymphoid tissues, gastrointestinal tract, testis and glandular cells of female genitalia.

Single cell type specificity Cell type enhanced (Spermatocytes, Erythroid cells, Extravillous trophoblasts, Early spermatids, Cytotrophoblasts)

Immune cell specificity: Immune cell enhanced (T-reg)

Subcellular summary HPA Located in Cytokinetic bridge (Single cell variability, CCD Protein, CCD Transcript)

Cancer prognostic summary HPA Prognostic marker in renal cancer (unfavorable), liver cancer (unfavorable) and lung cancer (unfavorable)

Pathology link: https://www.proteinatlas.org/ENSG00000089685-BIRC5/pathology

Pathology endo: https://www.proteinatlas.org/ENSG00000089685-BIRC5/pathology/endometrial+cancer

OMIM: 603352

OMIM link2: https://www.omim.org/entry/603352

HGNC ID: HGNC:593

HGNC link: https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:593