Biomarker: STC2

Histology type: endometrioid endometrial carcinoma

Country: Turkey

Region: Antalya

Followed up time :

Subgroup 1 name : High expression

Subgroup 1 number: 21

Subgroup 2 name: Low expression

Subgroup 2 number: 9

Conclusion: In conclusion, high-expression of STC2 is a negative prognostic factor, associated with increased risk of recurrence in endometrioid EC.

Sample type : tissue

Sample method: immunoreactivity

Expression pattern : high-expression(2 to 3+)

Expression elevation: The staining intensity was graded as follows: 0 = no staining; 1 = weak staining; 2 = moderate staining; and 3 = strong staining. The percentage of tumor cell staining was graded based on the following criteria: 0 = no staining; 1 = ≤10% of positive tumor cells; 2 = 11–50% of positive tumor cells; 3 = 51–80% of positive tumor cells; and 4 = ≥81% of positive tumor cells. The staining score for STC2 was calculated based on the sum of grades of staining intensity and percentage of staining, ranging from 0 to 7. A negative expression (0) was defined as no staining or ≤ 10% of cells stained regardless of intensity. A total grade of 3 was classified as 1+ expression; 4 to 5 as 2+ expression; and 6 to 7 as 3+ expression. The expression levels of STC2 were re-classified according to the three tiered semiquantitative scheme: negative expression, expression level of 0; low-expression, expression level of 1+; and high-expression, expression levels of 2+ and 3 + .

Statictics: Median;Range

Cohort age: 57 ;39–77

Funtion Uniprot: Has an anti-hypocalcemic action on calcium and phosphate homeostasis.

UniProt ID: O76061

UniProt Link: https://www.uniprot.org/uniprotkb/O76061/entry

Molecular function from UniProt:

Tissue specificity from UniProt: Expressed in a variety of tissues including muscle, heart, pancreas, kidney, spleen, prostate, small intestine, colon and peripheral blood leukocytes.

Subcellular UniProt: #Secreted

Alternative name from UniProt:

Recommended name: Stanniocalcin-2

Gene name from HGNC: STC2 (STC-2)

AlphaFold DB: O76061

AlphaFold Link: https://alphafold.ebi.ac.uk/entry/O76061

HPA link: https://www.proteinatlas.org/ENSG00000113739-STC2

Tissue specificity RNA from HPA: Tissue enriched (breast)

Tissue expression from HPA: Cytoplasmic or membranous expression in most tissues.

Single cell type specificity Cell type enhanced (Breast glandular cells, Breast myoepithelial cells, Extravillous trophoblasts)

Immune cell specificity: Low human brain regional specificity

Subcellular summary HPA Located in Endoplasmic reticulum

Cancer prognostic summary HPA summary Prognostic marker in renal cancer (unfavorable), head and neck cancer (unfavorable), liver cancer (unfavorable), breast cancer (favorable) and stomach cancer (unfavorable)

Pathology link: https://www.proteinatlas.org/ENSG00000113739-STC2/pathology

Pathology endo: https://www.proteinatlas.org/ENSG00000113739-STC2/pathology/endometrial+cancer

OMIM: 603665

OMIM link2: https://www.omim.org/entry/603665

HGNC ID: HGNC:11374

HGNC link: https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:11374