Pubmed Biomarker Relation P-value Description
34410950 cytoplasmic LCOR highe grade p=0.003 The cytoplasmic LCOR IRS was correlated statistically significantly with tumor grade as higher grades were associated with lower cytoplasmic LCOR IRS .
33059604 MCM5 high grade Overall sensitivity for endometrial cancer was 87.8% and remained high for low grade disease.(85.7,95% CI: 57.2–98.2%)
18458692 ADAM19 low grade p=0.028 Those with lower histological grade had a higher expression level
18431720 beta-catenin higher grade p<.0001 For β-catenin immunoreactivity, an increase in cytoplasmic and nuclear β-catenin expression and a loss of β-catenin expression appeared to be useful for the correct diagnosis of EC in endometrial cytology and may aid in the stratification of EC into low grade and high grade EC.
18431720 p53 high grade p<0.05 For p53 immunoreactivity, the application of a cutoff score ≥4 for nuclear p53 expression appeared to be useful for the diagnosis of high-grade EC in endometrial cytology.
18289648 TAMs high grade p=0.008 Margin TAMs were significantly associated with histological grade
17980190 serum p53 antibody (S-p53 Ab) G3 p=.005 S-p53 Ab-positive rate was significantly correlated with SA histology and grade 3 EA tumor.(odds ratio, 40,95% confidence interval, 3.04-525.43)
17885673 IMP3 high grade p=0.0002 Expression of IMP3 in endometrioid adenocarcinoma correlates with higher architecture grades of the tumor
17527071 MSI higher grade p=0.039 It showed orderly increase in the frequencies of MSI-high phenotype in higher histologic grade(13% vs. 21% vs. 50% in histologic grade I, II, and III)
17504383 beta-catenin low grade p=0.007 Positive beta-catenin expression was significantly associated with decreased grade
17139987 CD24 high grade p=0.011 Membranous staining of CD24 was significantly associated with the the International Federation of Gynecology grade
17139987 CD24 high grade p=0.002 Cytoplasmic staining of CD24 was significantly associated with the International Federation of Gynecology grade
32897964 Nuclear Beta-Catenin differentiation p<0.01 Cases with tubal differentiation were significantly less likely to demonstrate nonmorular BC than cases with no specific pattern of differentiation
17130035 oestrogen receptor low grade p<0.001 As the grade increased, oestrogen receptor expression in tumour cells decreased.
17108150 ephrinB2/EphB4 higher grade p<0.01 Both the histoscores and mRNA levels of EphB4 significantly increased with dedifferentiation (G(1) < G(2) < G(3),
16999816 PRB higher grade p=0.002 PRB isoform expression was significantly lower in the cases with higher histological grade
16999816 PRA higher grade p=0.0001 PRA isoform expression was significantly lower in the cases with higher histological grade
16980945 AIB1 higher grade p=0.04 AIB1 expression correlates with higher grade of carcinomas
16892013 GLUT1 and GLUT8 higher grade p<0.002 Upregulation of GLUT1 expression was demonstrated with increasing grade of tumors
16888409 TADG-14/KLK8 low grade p=0.0195 hK8 expression was significantly higher grade 1/2 of the tumors
16803534 E-cadherin, alpha-catenin, and beta-catenin G3 p<0.001 Negative E-cadherin, alpha-catenin, and beta-catenin expression was observed in 44%, 47%, and 33% of endometrial carcinomas, respectively, and was correlated with histologic FIGO grade 3
16311121 Aurora B high grade p=.028 There was no difference in PI or positive rate according to FIGO stage. However, the mean PI for Aurora B was significantly higher in high-grade tumors (grade 1, 0.2 ± 0.5; grade 2, 0.3 ± 1.0; grade 3, 0.7 ± 0.9)
16311121 Aurora B G3 p<.001 The positive rate for Aurora B in grade 3 tumors (77% [10/13]) was also significantly higher than that in grade 1 + 2 tumors (25% [15/60])
32769331 TROP2 higher grade High overexpression of TROP2 was seen in higher-grade
16311121 Aurora B G3 p=.0215 Multivariate analysis using the 3 variables (stage, grade, and Aurora B) showed that independent prognostic indicators for grade 3 tumors
16080017 skp2 grade Skp2 expression was increased significantly in those of higher histological grade.
15938112 HER-2+Ki-67 higher grade Overexpression of oncoprotein HER-2 and Ki-67 higher than median (42%) was associated with high tumor aggression resulting finally in a significant fall in the survival (from 75% to 58% and from 79% to 60%, respectively).
15790435 ATP7B higher grade p=0.019 ATP7B positivity in the degree of differentiation of G2 and G3 carcinoma was significantly higher than that of G1 carcinoma
15328195 E-Cadherin low grade p=0.15 E-Cadherin expression was negatively correlated with grade(Kendall tau: -0.13)
15218296 placental leucine aminopeptidase higher grade p<0.01 There was a positive correlation between the expression of P-LAP and histological grade
15032075 p53 higher grade p=.0001 p53 protein was expressed exclusively in invasive tumors and was related strongly to grade
12798703 Elf-1 G3 p<0.01 Scoring on the basis of the percentage of nuclear-positive cells indicated that nuclear Elf-1 expression was significantly associated with histological grade,
12747468 CD44 variant 6 higher grade CD44v3-expression correlated significantly with histologic grade
12684410 KAI1 poor differentiation p<0.001 More poorly differentiated tumors demonstrated significantly lower KAI1 expression as compared with the well-differentiated tumors.
32630554 MSX1 G2 p=0.001 A significant stronger expression of MSX1 was found in grading 2 (moderate differentiation)
12130664 UPAR grade p<0.0001 High UPAR expression positively correlated with grade of disease(ungrouped Spearman correlation = 0.71)
12073048 Cyclin A higher grade p<0.05 Cyclin A expression increased significantly in higher histological grades (G1 vs G2)
12073048 Cyclin A higher grade p<0.01 Cyclin A expression increased significantly in higher histological grades G2 vs G3
11431715 telomerase higher grade p=.003 Telomerase activity was detected in 50 of 53 ECs (94%). Its levels correlated significantly with FIGO grade
11275368 Id1 G3 p<0.05 Id1 was strongly expressed in the inflammatory cells. Scoring on the basis of the percentage of positive cells indicated that Id1 expression is significantly associated with histological grade
10878548 metallothioneins higher grade p=0.0065 In carcinomas, MT expression was positively correlated with grade
10600396 p53 G3 p=0.008 Deletion of p53 was seen in 31/47 (66%) cases and was associated with poor histologic grade
9934583 Ki-S4 PA G3 p<0.001 The number of Ki-S4 positive cells (median 28.9%, IR 24±33%) was significantly higher in endometrial carcinomas designated as grade 3 than in tumours designated as grade 2 (median 19.1%, IR 16±24%) or grade 1 (median 9.5%, IR 6±14)
9648591 PR higher grade p=0.007 PR immunohistochemistry of endometrial carcinoma was statistically correlated with FIGO grade (G1 vs G2 vs G3
9646853 HER-2/neu higher grade p=0.030 The intensity of the immunostaining and the number of cells stained for HER-2/neu oncogene had no significant association with surgical stage or histologic grade, although the proportion of patients demonstrating overexpression increased significantly as the histologic grade of their tumor increased
32433831 COX-2 G3 p<.001 Positive expression of COX-2 was found mainly in high (59.2% grade 3) than low (17.5% grade 2 and 0.0% grade 1) grade carcinomas.
8695259 p53 G3 p<0.0001 Strong p53 expression (> 75% of the cells stained) was more common in uterine papillary serous cancers and clear cell cancers than in tumours with nuclear grade 3
8575739 apoptotic index G3 Two grade 3 adenocarcinomas of endometrium had a higher apoptotic index (5.15% to 6.43%) than 13 grade 1 and 2 lesions (1.18% to 3.8%) and formed a distinct group in this series
8112955 AgNOR morphology grade The AgNOR morphology correlated significantly with grade
7631667 colony-stimulating factor 1 grade p=0.0002, The serum CSF-I levels correlated with the FIG0 histologic grade
7631667 colony-stimulating factor 1 G3 p=0.0166 The frequencies of pathologically elevated CSF-1 were significantly higher in grade 3 than in grade 1 and 2 tumors.
27898420 BANCR higher grade p=0.023 The level of BANCR expression was correlated with grade
35729354 SLeX p<0.001 High expression of SLeX was correlated to low pT-stage (p = 0.013), low grade
35449078 cell free DNA G1 and G2 grades p<0.05 MCA indicates cfDNA, cfmtDNA and citH3 as features associated to G1 and G2 grades.
35449078 cell free mitochondrial DNA G1 and G2 grades p=0.044 MCA indicates cfDNA, cfmtDNA and citH3 as features associated to G1 and G2 grades.
35449078 citrullinated histone H3 G1 and G2 grades MCA indicates cfDNA, cfmtDNA and citH3 as features associated to G1 and G2 grades.
30684972 RRBP1 high grade p=0.005 High levels of expression of RRBP1 were strongly correlated with high histological grades
35241527 VEGFR2 p=0.004 Higher expression of VEGFR2 was associated with lower International Federation of Obstetrics and Gynecology grades
35241527 VEGFR2 p=0.004 The positive correlation between HER2 and VEFR2 expression was statistically significant in T1 stage (p=0.002) and International Federation of Obstetrics and Gynecology grade 1 tumors
35533253 PKN1 P =0 .06 PKN1 expression increased along the higher FIGO grade .
36251972 p53 P <0.001 Abnormal p53 IHC expression was expressed in 33.3% of the cases and significantly associated with the tumor grade, myometrial invasion (MI), lymphovascular invasion (LVSI), nodal metastasis, and FIGO stage, and the advanced European Society for Medical Oncology (ESMO) risk groups.
36251972 L1CAM P =0.003 Positive L1CAM immunoexpression was noted in 26.7% and was significantly associated with grade.
35941559 ADC p = 0.022 and 0.047 ADCminand ADC10thwere significantly lower in Grade 3 than in Grade 1/2 stage IA EC (p = 0.022 and 0.047).
30661222 STC2 grade 2-3 p=0.026 High-expression of STC2 was significantly associated with grade 2-3 tumors
30591489 L1CAM G3 p=0.02 L1CAM positivity was significantly more common in grade 3 compared to grade 1-2 carcinomas
30539847 HIF-1α highe grade p=0.014 HIF-1α expression was significantly associated with tumor grade
30479213 Endoglin G1 Analysis of studied protein level showed that the optical density of the immunohistochemical reaction product in G1 reached 145% of the value observed in the control
34339705 SOX17 low grade p=0.019 SOX17 positive expression was positively correlated with grade
30479213 Endoglin G2 In G2, the optical density was lower than in G1, accounting for 110% of the control. T
30479213 Endoglin G3 The level of endoglin in G3 was the highest among all the studied groups and reached almost 160% of the control group
30134343 PD-L1 high grade p=0.009 There was a statistically significant association between the FIGO grade and the PD-L1 score in immune cells
29984790 MACC1/c-Myc grade p<0.05 MACC1/c-Myc expression was correlated with primary infiltration grade
29980240 L1CAM G3 p=0.004 Higher L1CAM expression predicted a significant shorter DFS in the subgroup of patients with G3 tumor.(5y-DFS, 67.7% vs 16.6%,)
29980240 L1CAM G3 p=0.01 High level of L1CAM were associated with lower DFS in patients with G3
29907137 GLP-1R high grade p< 0.001 Higher expression of GLP-1R was significantly correlated with high grade.
29653556 DFF40+ G1-G2 p<0.001 DFF40+ significantly higher in Group A(Low- and moderate- grade endometroid endometrial cance) than in Group B (Non-endometrioid and high-grade endometroid endometrial cancer)
29653556 BCL2 G1-G2 p<0. 001 BCL2 significantly higher in Group A(Low- and moderate- grade endometroid endometrial cance) than in Group B(Non-endometrioid and high-grade endometroid endometrial cancer)
29526558 TRIM44 high grade p<0.05 TRIM44 overexpression was associated with histological grade
34331128 microRNA-21 highe grade p<0.0001 High miR-21 expression in cancer cells was associated with a higher histological grade (G3 vs. G1, G2 in endometrioid carcinoma)
29382392 DNA integrity index high grade p<.05 Decreased DNA integrity values significantly correlated with the hypertensive status in high grade ECs with the presence of LVSI.(likelihood ratio chi square = 3.691)
29169184 HER2 high grade p<0.001 A gradual increase in number of HER2 high tumours was observed according to aggressiveness of histologic type and grade
29114696 cancer antigen 15-3 levels G3 p=0.009 The mean serum CA15-3 levels were significantly higher in Grade 3 tumors (31.7±30.7 [4.0−153.0] IU/mL) compared to Grade 1 (17.9±7.8 [8.0–38.0] IU/mL)
29114696 cancer antigen 15-3 levels G3 p=0.02 The mean serum CA15-3 levels differed significantly according to histological grade (p=0.007). Post-hoc Tukey analyses revealed that the mean serum CA15-3 levels were significantly higher in Grade 3 tumors (31.7±30.7 [4.0−153.0] IU/mL) compared to Grade 2 tumors (19.4±8.5 [4.0–41.0] IU/mL;
29096882 Asparaginase-like protein 1 higher grade p<0.001 The proportion of lesions with low ASRGL1 expression increased significantly with higher grade within the endometrioid endometrial carcinoma subgroup
29096882 Asparaginase-like protein 1 G3 p=0.012 Of the non-endometrioid tumors 56% had low expression of ASRGL1, which was significantly higher than for the endometrioid grade 3 tumor
28836043 NTSR1 high grade p=0.0008 NTSR1 messenger RNA (mRNA) was positively correlated with the grade
28794448 CD133 low grade p=0.034 CD133+ status differed depending on the histological grade.
28668893 GalNAc-T6 low grade p=0.002 Positive GalNAc-T6 expression was associated with histological grade of the tumor
28618925 DJ-1 grade 2-3 p≤0.05 DJ-1 levels were significantly higher in the EEC-G2 (586 pg/mL), EEC-G3 (1015 pg/mL), and in the non-EEC (SEC/CCEC) patients (1395 pg/mL) compared to the EEC-G1 group and to the healthy subjects
34331128 microRNA-21 high grade p<0.0001 High miR-21 expression in cancer cells was associated with a higher histological grade (high- vs. low-grade cancer in all endometrial cancersa)
28618925 DJ-1 EEC p≤0.05 The difference of DJ-1 serum levels remains statistically significant when we compared EEC-G3 and SEC/CCEC versus EEC-G2
28232277 STAR high grade p=0.009 Mann-Whitney U tests revealed significantly decreased expression of STAR in high grade versus low grade tumors.(4.4-fold; adjusted)
28232277 AKR1B10 high grade p=0.003 Mann-Whitney U tests revealed significantly decreased expression of AKR1B10 in high grade versus low grade tumors.(9-fold; adjusted)
28215640 galectin-3 G1 p=0.043 Tumor grade was significantly associated with galectin-3 immunoreactivity cases with membranous and cytoplasmic staining is significantly associated with grade I and stage II, while cases with loss of staining are more frequent in grade II, III and poorly differentiated tumors
28187032 Tyrosine Phosphatase SHP-1 G1 p=0.0243 In the Ec group, SHP-1 immunoreactivity was correlated with grading, demonstrating that more differentiated lesions expressed SHP-1 more frequently than less differentiated neoplasms (G1 vs. G2,statistically significant value, Fisher exact test;
28187032 Tyrosine Phosphatase SHP-1 G1 p=0.0088 In the Ec group, SHP-1 immunoreactivity was correlated with grading, demonstrating that more differentiated lesions expressed SHP-1 more frequently than less differentiated neoplasms G1 vs. G3 statistically significant value, Fisher exact test;
28155970 p53 high grade p<0.001 p53 staining patterns can differentiate between high-grade EAC and USC. A discrimination score was obtained for p53, which was found to be statistically significant
28155970 p53 grade p<0.05 p53 staining was significantly lower in grade 1 endometrioid carcinoma
28155970 p53 high grade p<0.001 p53 staining was differentiate between high-grade endometrioid and serous carcinoma
28155970 Ret finger protein G3 p<0.05 RFP scores were higher in both USC and grade 3 EAC cases (p > 0.05), whereas they were significantly lower in grade 1 EAC
34331128 microRNA-21 high grade p=0.030 High miR-21 expression in stromal cells was associated with higher histological grade in endometrioid carcinoma ( G3 VS G1-G2 )
28155970 Ret finger protein G3 p<0.001 The RFP score was found to be significantly higher in grade 3 EAC and USC. The area under the ROC curve for USC and grade 3 EAC was 0.597 and was not found to be statistically significant. However, the ROC analysis result was 0.776 for serous versus grade 1 EAC
28155970 Ret finger protein G3 The RFP score was found to be significantly higher in grade 3 EAC and USC. The area under the ROC curve for USC and grade 3 EAC was 0.597 and was not found to be statistically significant. However, the ROC analysis result was 0.44 for grade 3 EAC versus grade 1 EAC
27974701 lamin A G1 Data obtained by comparing lamin A mRNA levels in the two subgroups of G1 EEC tissues indicated that lamin A reduction was significantly higher in NF-YAs positive with respect to NF-YAs negative sample
27974701 lamin A high grade Levels of lamin A in NF-YAs positive tissues were comparable to that of high grade EEC.
27540975 UCA1 high grade p=0.009 High UCA1 expression was observed to be closely correlated with grade
27512000 GGT G3 p<0.001 In G3 tumours, GGT expression was significantly lower (0.0, S.E.M. = 0.07) than in healthy endometrium
26985869 MIF G1 p=0.013 MIF protein expression was significantly lower in endometrial carcinoma with low grading G1
26985869 MIF G1 p=0.001 MIF protein had a higher expression in tumors at grade G1.(χ2=11.064)
26985869 c-erbB-2 grade G2–G3 p=0.009 C-erbB-2 protein expression was higher in tumors at grade G2–G3.(χ2=6.788)
26985869 MIF low grading G1 p=0.004 MIF mRNA overexpression appeared to correlate with lower aggressiveness: It was significantly associated with low grading G1
34306255 GABPA high grade p<0.05 The expression of GABPA was markedly correlated with grade 3 EC
26985869 c-erbB-2 grading G2-3 p=0.001 The analysis demonstrated that the levels of c-erbB-2 mRNA were higher in grading G2-3 compared with low grading G1.(2.291±1.231 vs. 4.323±1.221)
26708131 Co-expression GAL-3 and CRIP-1 high grade There was a significant correlation between high co-expression of the two proteins and the histological grade.(aOR 2.66)
26678075 sialyl Tn (STN) high grade p=0.02 Elevated serum STN levels were associated with histological grade of the tumor
26647729 CCNE1 G3 p=0.0087 CCNE1 amplification were correlated with high histological grade (Grade 3
26260911 Metabolic syndrome high grade p=0.022 MS was closely related to grade
26245990 CDC20 high grade p=0.016 High expression of CDC20 was associated with high tumor grade in the endometria carcinomas
26191146 Musashi-1 protein high grade p =0.000 The expression of Musashi-1 showed significant difference in tumor grade, and higher staining displayed in high-grade than in low-grade.(χ2 = 26.957)
26166558 LSD1 high grade p<0.001 LSD1 overexpression was significantly associated with the advanced extent of EEA, such as a high histological grade
25874492 Sam68 high grade p<0.001 The high expression of Sam68 was associated with histological grade
25544793 ZEB1 high grade p=0.022 The ZEB1 expression in endometrial biopsy significantly associated with grade
33635467 BMP-10 high grade p<0.001 BMP-10 expression was significantly correlated with histological grade
25505230 POLE proofreading mutations high tumor grade p<.001 POLE mutations were detected in 48 of 788 (6.1%) ECs from PORTEC-1 and-2 and were associated with high tumor grade
25355598 HABP1 higher grade p<0.001 High HABP1 expression was significantly associated with higher histologic grade
25315186 cyclin B higher grade Cyclin B expression correlated with grade
24972085 Yes-associated protein (YAP) higher grade p=0.019 Increased nuclear YAP expression was significantly associated with higher grade
24930886 KPNA2 higher grade p=0.026 KPNA2 expression was significantly up-regulated in human endometrial carcinomas and associated with higher tumour grade
24849812 FOXA1 higher grade p=0.003 Low FOXA1 expression (score index from 0–4) was significantly correlated with high histologic grade
24614826 DJ-1 G3 DJ-1 IHC score was significantly higher in ESC versus those EEC G1-G2. In 3 cases of EEC G3, the DJ-1 expression was similar to the ESC subtype.
24590269 TNFAIP8 higher grade p=0.017 An association was observed between TNFAIP8 overexpression and higher histologic grade
24228101 URI/RMP G3 p<0.05 URI/RMP staining intensity of Grade III tumors (0.0788±0.0170, n=7) is significantly higher than that of adjacent tissues (0.0345±0.0156, n=7
23334889 Mad2 higher grade p=0.002 The higher positive rate of Mad2 were related to histological grade of endometrial cancer
33528032 HE4 high grade Serum HE4 detecting high-grade disease sensitivity 75%
22889453 PKM2 higher grade p=0.008 The positive rate of PKM2 in grades 1 and2–3 EC samples were 45.3% (34/75) and 70.5% (31/44),respectively
22889453 HSPA5 grade G2–G3 p=0.03 The positive rate of HSPA5 in grades 1 and2–3 EC samples were 58.7% (44/75) and 77.3% (34/44),respectively
22784357 fascin high grade p=0.003 Fascin expression was significantly correlated with tumour grade
22644303 pHH3 high grade p<0.0001 Patients with high-grade tumours expressed significantly more pHH3 than low grade
22644303 survivin high grade p<0.0001 Patients with high-grade tumours expressed significantly more survivin than low grade
22644303 pHH3 high grade p<0.0001 The rate of pHH3-positive cells was significantly associated with histological grade
22412054 podocalyxin high grade p=0.0001 Podocalyxin expression was correlated with tumour grade
22209294 phosphatidylinositol 3'-kinase pathway alteration high grade p=.045 Mutations of both exons were more common in low-grade than in high-grade endometrioid carcinomas, and the correlation between exon 9 mutation and lower grade was statistically significant
22146769 SPAG9 G3 p=0.003 Patients harboring grade 3 endometrial carcinoma were found to have significantly higher SPAG9 concentrations than those of grade 1/grade 2
22116456 endoglin higher grade p<0.001 The endoglin protein level demonstrated significant upregulation associated with increased tumor malignancy, assessed by histological grade and myometrium infiltration.
33528032 HE4 discrimination serum HE4 detecting high-grade disease specificity 50%
22037740 Endometrial CA-125 +serum CA-125expression higher grade p=0.0004 There was a significant difference in endometrial CA-125 expression among patients with pathological grade 1, 2 and 3 of endometrial carcinoma.(χ2=15.632)
22037740 Endometrial CA-125 +serum CA-125expression grade p=0.0058 The endometrial expression of CA-125 in each grade of cancer was significantly different from that of normal endometrium. There was a significant difference in CA-125 expression between grade 1 and 3 endometrial carcinoma,whereas there was no significant difference in CA-125 expression between grade 1 and 2 endometrial carcinoma (P=0.0717 by Fisher’s exact test).
22015044 Synuclein-γ (SNCG) protein higher grade p=<0.001 There was a strong association between SNCG+ and high tumor grade
21741077 Beclin 1 higher grade A high Beclin 1 reactivity occurred in 18.1% of endometrial adenocarcinomas studied and was associated with high tumor grade,
21616994 GDF-15 higher grade p≤0.001 High plasma GDF-15 was significantly associated with high grade,
21468050 HE4 low grade p<0.0001 Immunostaining of HE4 was significantly greater in G1 and in G2 tumours compared with G3 ones
21103625 MVD higher grade MVD counts of patients with G1 EC was lower than patients with G2 and G3 EC.
21103625 VEGF G1 The positive immunoreactions for VEGF were significantly more frequent in G1 EC in comparison to the patients with G2 + G3 EC.
19823058 FAK higher grade p=0.002 Increased expression of FAK correlated with higher histological tumor grade
19509570 p53 higher grade p< 0.0001 P53 expression was related to a hig tumor grade

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